Detailed information of TA system TA180974

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 549354..549574
• Replicon: chromosome
• Accession: NZ_CP064374
• Organism: Enterococcus faecalis strain PartL-Efaecalis-RM8376

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: IUJ47_RS02710
• Protein ID: WP_021164441.1
• Coordinates: 549473..549574 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	549354..549528 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUJ47_RS02685	545001..545954	-	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-
IUJ47_RS02690	545993..546748	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
IUJ47_RS02695	546745..547710	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
IUJ47_RS02700	547707..548654	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
IUJ47_RS02705	548839..549291	+	453	WP_002389410.1	YueI family protein	-
-	549354..549528	+	175	-	-	Antitoxin
IUJ47_RS02710	549473..549574	-	102	WP_021164441.1	putative holin-like toxin	Toxin
IUJ47_RS02715	549906..550007	-	102	WP_075551663.1	putative holin-like toxin	-
IUJ47_RS02720	550197..552467	-	2271	WP_002389492.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
IUJ47_RS02725	552638..553138	+	501	WP_002372831.1	cysteine hydrolase family protein	-
IUJ47_RS02730	553537..554433	+	897	WP_002389477.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3598.36 Da
• Isoelectric Point: 6.0656

>T180974 WP_021164441.1 NZ_CP064374:c549574-549473 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

>T180974 NZ_CP085796:c160362-159994 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT180974 NZ_CP064374:549354-549528 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAA
TCAGTAGTGCAACAA

Structures

Antitoxin