Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | DinJ-YafQ (relBE)/YafQ-RelB |
| Location | 1212..1751 | Replicon | plasmid unnamed4 |
| Accession | NZ_CP064372 | ||
| Organism | Klebsiella pneumoniae strain PartO-Kpneumoniae-RM8376 | ||
Toxin (Protein)
| Gene name | yafQ | Uniprot ID | J2DZM3 |
| Locus tag | IUJ50_RS26825 | Protein ID | WP_004150484.1 |
| Coordinates | 1476..1751 (+) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | dinJ | Uniprot ID | A0A5H6MLU0 |
| Locus tag | IUJ50_RS26820 | Protein ID | WP_001570852.1 |
| Coordinates | 1212..1472 (+) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IUJ50_RS26815 (IUJ50_26740) | 690..947 | + | 258 | WP_025862334.1 | hypothetical protein | - |
| IUJ50_RS26820 (IUJ50_26745) | 1212..1472 | + | 261 | WP_001570852.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| IUJ50_RS26825 (IUJ50_26750) | 1476..1751 | + | 276 | WP_004150484.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| IUJ50_RS26830 (IUJ50_26755) | 1702..1908 | + | 207 | WP_004150485.1 | hypothetical protein | - |
| IUJ50_RS26835 (IUJ50_26760) | 1920..2123 | - | 204 | WP_004150486.1 | hypothetical protein | - |
| IUJ50_RS26840 (IUJ50_26765) | 2455..2982 | + | 528 | WP_001570849.1 | ankyrin repeat domain-containing protein | - |
| IUJ50_RS26845 (IUJ50_26770) | 2993..3202 | + | 210 | WP_001570848.1 | hypothetical protein | - |
| IUJ50_RS26850 (IUJ50_26775) | 3199..3456 | + | 258 | WP_004150488.1 | hypothetical protein | - |
| IUJ50_RS26855 (IUJ50_26780) | 3457..3879 | + | 423 | WP_004150489.1 | hypothetical protein | - |
| IUJ50_RS26860 (IUJ50_26785) | 3876..4169 | + | 294 | WP_001570846.1 | hypothetical protein | - |
| IUJ50_RS27110 | 4181..4303 | + | 123 | WP_004150490.1 | hypothetical protein | - |
| IUJ50_RS26865 (IUJ50_26790) | 4305..4616 | + | 312 | WP_058820517.1 | hypothetical protein | - |
| IUJ50_RS26870 (IUJ50_26795) | 4619..5176 | + | 558 | WP_004150493.1 | type 4 pilus major pilin | - |
| IUJ50_RS26875 (IUJ50_26800) | 5192..5731 | + | 540 | WP_004150494.1 | type 4 pilus major pilin | - |
| IUJ50_RS26880 (IUJ50_26805) | 5748..5993 | + | 246 | WP_004150495.1 | hypothetical protein | - |
| IUJ50_RS26885 (IUJ50_26810) | 6067..6513 | - | 447 | WP_004150496.1 | H-NS family nucleoid-associated regulatory protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..45158 | 45158 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10750.40 Da Isoelectric Point: 9.6586
>T180969 WP_004150484.1 NZ_CP064372:1476-1751 [Klebsiella pneumoniae]
MTTRTIEYSGQFQKDVKKAQKRHKDMSKLKALMTLLINDALPLPQVYKDHPLQGNYKGYRDAHIEPDWLLIYKITDEVLR
FERTGTHSDLF
MTTRTIEYSGQFQKDVKKAQKRHKDMSKLKALMTLLINDALPLPQVYKDHPLQGNYKGYRDAHIEPDWLLIYKITDEVLR
FERTGTHSDLF
Download Length: 276 bp
>T180969 NZ_CP085795:c2248594-2248337 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG
Antitoxin
Download Length: 87 a.a. Molecular weight: 9239.63 Da Isoelectric Point: 5.0336
>AT180969 WP_001570852.1 NZ_CP064372:1212-1472 [Klebsiella pneumoniae]
MAANAFVRARIDETLKNEAAVVLAGMGLTVSDLVRITLTKVAKEKALPFDMRVPNELTANTIANSEKGVDVHTAKDADDL
FNQLGI
MAANAFVRARIDETLKNEAAVVLAGMGLTVSDLVRITLTKVAKEKALPFDMRVPNELTANTIANSEKGVDVHTAKDADDL
FNQLGI
Download Length: 261 bp
>AT180969 NZ_CP085795:2248419-2248751 [Salmonella enterica subsp. enterica serovar Enteritidis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | J2DZM3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5H6MLU0 |