Detailed information of TA system TA180938

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1646215..1646478
• Replicon: chromosome
• Accession: NZ_CP064365
• Organism: Staphylococcus aureus strain PartF-Saureus-RM8376

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IUJ41_RS08200
• Protein ID: WP_001802298.1
• Coordinates: 1646215..1646319 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	1646314..1646478 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUJ41_RS08170 (IUJ41_08145)	1641599..1642381	+	783	WP_000908177.1	ABC transporter ATP-binding protein	-
IUJ41_RS08175 (IUJ41_08150)	1642449..1643306	+	858	WP_000370924.1	HAD family hydrolase	-
IUJ41_RS08185 (IUJ41_08155)	1644011..1644103	-	93	WP_001790138.1	hypothetical protein	-
IUJ41_RS08190 (IUJ41_08160)	1644392..1645528	+	1137	WP_000115562.1	SAP domain-containing protein	-
IUJ41_RS08195 (IUJ41_08165)	1645571..1646054	+	484	Protein_1604	recombinase family protein	-
IUJ41_RS08200 (IUJ41_08170)	1646215..1646319	+	105	WP_001802298.1	hypothetical protein	Toxin
-	1646314..1646478	-	165	-	-	Antitoxin
IUJ41_RS08210 (IUJ41_08175)	1646819..1647910	-	1092	WP_000495671.1	lytic regulatory protein	-
IUJ41_RS08215 (IUJ41_08180)	1648176..1649156	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
IUJ41_RS08220 (IUJ41_08185)	1649158..1649478	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IUJ41_RS08225 (IUJ41_08190)	1649630..1650295	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T180938 WP_001802298.1 NZ_CP064365:1646215-1646319 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T180938 NZ_CP085793:c4209802-4209527 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT180938 NZ_CP064365:c1646478-1646314 [Staphylococcus aureus]
GTAGCAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin