Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 1380776..1381293 | Replicon | chromosome |
| Accession | NZ_CP064365 | ||
| Organism | Staphylococcus aureus strain PartF-Saureus-RM8376 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | IUJ41_RS06815 | Protein ID | WP_000113262.1 |
| Coordinates | 1381027..1381293 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | IUJ41_RS06810 | Protein ID | WP_000584499.1 |
| Coordinates | 1380776..1381027 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IUJ41_RS06780 (IUJ41_06755) | 1376474..1377193 | + | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
| IUJ41_RS06785 (IUJ41_06760) | 1377190..1377921 | + | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| IUJ41_RS06790 (IUJ41_06765) | 1378018..1379268 | - | 1251 | WP_001012222.1 | FemA/FemB family glycyltransferase FmhA | - |
| IUJ41_RS06795 (IUJ41_06770) | 1379523..1379885 | + | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| IUJ41_RS06800 (IUJ41_06775) | 1379904..1380503 | + | 600 | WP_000162813.1 | DsbA family protein | - |
| IUJ41_RS06805 (IUJ41_06780) | 1380510..1380611 | + | 102 | WP_001791744.1 | hypothetical protein | - |
| IUJ41_RS06810 (IUJ41_06785) | 1380776..1381027 | + | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| IUJ41_RS06815 (IUJ41_06790) | 1381027..1381293 | + | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| IUJ41_RS06820 (IUJ41_06795) | 1381328..1381399 | + | 72 | Protein_1338 | hypothetical protein | - |
| IUJ41_RS06825 (IUJ41_06800) | 1381588..1383138 | + | 1551 | WP_000727762.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| IUJ41_RS06830 (IUJ41_06805) | 1383324..1383791 | + | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| IUJ41_RS06835 (IUJ41_06810) | 1383875..1384057 | + | 183 | WP_000230294.1 | hypothetical protein | - |
| IUJ41_RS06840 (IUJ41_06815) | 1384274..1385098 | + | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| IUJ41_RS06845 (IUJ41_06820) | 1385331..1385867 | + | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T180937 WP_000113262.1 NZ_CP064365:1381027-1381293 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T180937 NZ_CP085793:c3743472-3743059 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT180937 WP_000584499.1 NZ_CP064365:1380776-1381027 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT180937 NZ_CP085793:c3743719-3743453 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|