Detailed information of TA system TA180935

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1355757..1355941
• Replicon: chromosome
• Accession: NZ_CP064365
• Organism: Staphylococcus aureus strain PartF-Saureus-RM8376

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: IUJ41_RS06680
• Protein ID: WP_000482650.1
• Coordinates: 1355757..1355864 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1355881..1355941 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUJ41_RS06655 (IUJ41_06630)	1351119..1351592	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
IUJ41_RS06660 (IUJ41_06635)	1351715..1352926	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IUJ41_RS06665 (IUJ41_06640)	1353108..1353767	-	660	WP_000831298.1	membrane protein	-
IUJ41_RS06670 (IUJ41_06645)	1353827..1354969	-	1143	WP_001176863.1	glycerate kinase	-
IUJ41_RS06675 (IUJ41_06650)	1355237..1355623	+	387	WP_000779358.1	flippase GtxA	-
IUJ41_RS06680 (IUJ41_06655)	1355757..1355864	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	1355881..1355941	-	61	-	-	Antitoxin
IUJ41_RS06685 (IUJ41_06660)	1356492..1358255	+	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
IUJ41_RS06690 (IUJ41_06665)	1358280..1360013	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
IUJ41_RS06695 (IUJ41_06670)	1360244..1360411	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T180935 WP_000482650.1 NZ_CP064365:1355757-1355864 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T180935 NZ_CP085793:3579699-3580226 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT180935 NZ_CP064365:c1355941-1355881 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin