Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1323917..1324440 Replicon chromosome
Accession NZ_CP064365
Organism Staphylococcus aureus strain PartF-Saureus-RM8376

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag IUJ41_RS06540 Protein ID WP_000074048.1
Coordinates 1324174..1324440 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag IUJ41_RS06535 Protein ID WP_000587616.1
Coordinates 1323917..1324174 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ41_RS06515 (IUJ41_06490) 1318997..1320190 + 1194 WP_000675401.1 MFS transporter -
IUJ41_RS06520 (IUJ41_06495) 1320414..1321163 - 750 WP_000072443.1 CPBP family lipoprotein N-acylation protein LnsB -
IUJ41_RS06525 (IUJ41_06500) 1321358..1322935 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
IUJ41_RS06530 (IUJ41_06505) 1323103..1323558 - 456 WP_000732082.1 DUF1307 domain-containing protein -
IUJ41_RS06535 (IUJ41_06510) 1323917..1324174 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IUJ41_RS06540 (IUJ41_06515) 1324174..1324440 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
IUJ41_RS06545 (IUJ41_06520) 1324795..1325871 + 1077 WP_001076671.1 M42 family metallopeptidase -
IUJ41_RS06550 (IUJ41_06525) 1326119..1326781 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
IUJ41_RS06555 (IUJ41_06530) 1326774..1327550 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
IUJ41_RS06560 (IUJ41_06535) 1327946..1329133 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T180934 WP_000074048.1 NZ_CP064365:1324174-1324440 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T180934 NZ_CP085793:2090977-2091132 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT180934 WP_000587616.1 NZ_CP064365:1323917-1324174 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT180934 NZ_CP085793:c2090965-2090907 [Salmonella enterica subsp. enterica serovar Enteritidis]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References