Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 182544..182967 | Replicon | chromosome |
| Accession | NZ_CP064365 | ||
| Organism | Staphylococcus aureus strain PartF-Saureus-RM8376 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | IUJ41_RS00960 | Protein ID | WP_001836226.1 |
| Coordinates | 182716..182967 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | IUJ41_RS00955 | Protein ID | WP_000028421.1 |
| Coordinates | 182544..182726 (-) | Length | 61 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IUJ41_RS00910 (IUJ41_00900) | 178648..179943 | - | 1296 | WP_001836232.1 | PBSX family phage terminase large subunit | - |
| IUJ41_RS00915 (IUJ41_00905) | 179946..180440 | - | 495 | WP_001038244.1 | terminase small subunit | - |
| IUJ41_RS00920 (IUJ41_00910) | 180628..181050 | - | 423 | WP_000162701.1 | RinA family phage transcriptional activator | - |
| IUJ41_RS00925 (IUJ41_00915) | 181074..181220 | - | 147 | WP_000990005.1 | hypothetical protein | - |
| IUJ41_RS00930 (IUJ41_00920) | 181221..181394 | - | 174 | WP_001657250.1 | transcriptional activator RinB | - |
| IUJ41_RS00935 (IUJ41_00925) | 181387..181590 | - | 204 | WP_001072794.1 | hypothetical protein | - |
| IUJ41_RS00940 (IUJ41_00930) | 181587..181781 | - | 195 | WP_000132920.1 | hypothetical protein | - |
| IUJ41_RS00945 (IUJ41_00935) | 181778..181984 | - | 207 | WP_000195785.1 | DUF1381 domain-containing protein | - |
| IUJ41_RS00950 (IUJ41_00940) | 182021..182551 | - | 531 | WP_000185651.1 | dUTP pyrophosphatase | - |
| IUJ41_RS00955 (IUJ41_00945) | 182544..182726 | - | 183 | WP_000028421.1 | hypothetical protein | Antitoxin |
| IUJ41_RS00960 (IUJ41_00950) | 182716..182967 | - | 252 | WP_001836226.1 | DUF1024 family protein | Toxin |
| IUJ41_RS00965 (IUJ41_00955) | 182960..183331 | - | 372 | WP_001557190.1 | hypothetical protein | - |
| IUJ41_RS00970 (IUJ41_00960) | 183340..183582 | - | 243 | WP_001562543.1 | SAV1978 family virulence-associated passenger protein | - |
| IUJ41_RS00975 (IUJ41_00965) | 183586..183942 | - | 357 | WP_000029376.1 | SA1788 family PVL leukocidin-associated protein | - |
| IUJ41_RS00980 (IUJ41_00970) | 184070..184375 | - | 306 | WP_000101252.1 | hypothetical protein | - |
| IUJ41_RS00985 (IUJ41_00975) | 184376..184561 | - | 186 | WP_001187243.1 | DUF3113 family protein | - |
| IUJ41_RS00990 (IUJ41_00980) | 184566..184970 | - | 405 | WP_001836225.1 | DUF1064 domain-containing protein | - |
| IUJ41_RS00995 (IUJ41_00985) | 184980..185201 | - | 222 | WP_001123695.1 | DUF3269 family protein | - |
| IUJ41_RS01000 (IUJ41_00990) | 185214..185372 | - | 159 | WP_000256589.1 | hypothetical protein | - |
| IUJ41_RS01005 (IUJ41_00995) | 185366..186145 | - | 780 | WP_000803062.1 | ATP-binding protein | - |
| IUJ41_RS01010 (IUJ41_01000) | 186155..186925 | - | 771 | WP_001836222.1 | conserved phage C-terminal domain-containing protein | - |
| IUJ41_RS01015 (IUJ41_01005) | 186991..187272 | + | 282 | WP_000414755.1 | hypothetical protein | - |
| IUJ41_RS01020 (IUJ41_01010) | 187265..187414 | - | 150 | WP_001081076.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | vWbp | 153124..230377 | 77253 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9457.35 Da Isoelectric Point: 3.8049
>T180932 WP_001836226.1 NZ_CP064365:c182967-182716 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTGQVVYKYEEEQE
NEH
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTGQVVYKYEEEQE
NEH
Download Length: 252 bp
>T180932 NZ_CP085793:c1123000-1122782 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
Antitoxin
Download Length: 61 a.a. Molecular weight: 6683.59 Da Isoelectric Point: 4.3791
>AT180932 WP_000028421.1 NZ_CP064365:c182726-182544 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEAQEND
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEAQEND
Download Length: 183 bp
>AT180932 NZ_CP085793:c1123402-1123028 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|