180908

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5065930..5066521 Replicon chromosome
Accession NZ_CP064354
Organism Pseudomonas fragi strain NL20W

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IS178_RS23105 Protein ID WP_029611627.1
Coordinates 5066243..5066521 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag IS178_RS23100 Protein ID WP_016782667.1
Coordinates 5065930..5066235 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IS178_RS23070 5061386..5062072 + 687 WP_016782662.1 HAD family hydrolase -
IS178_RS23075 5062259..5062585 - 327 WP_016782663.1 hypothetical protein -
IS178_RS23080 5063066..5064403 - 1338 WP_083369719.1 ammonium transporter -
IS178_RS23085 5064437..5064775 - 339 WP_002555808.1 P-II family nitrogen regulator -
IS178_RS23090 5065193..5065453 + 261 WP_016782665.1 accessory factor UbiK family protein -
IS178_RS23095 5065500..5065928 + 429 WP_016782666.1 VOC family protein -
IS178_RS23100 5065930..5066235 - 306 WP_016782667.1 HigA family addiction module antidote protein Antitoxin
IS178_RS23105 5066243..5066521 - 279 WP_029611627.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IS178_RS23110 5066698..5068191 + 1494 WP_016782669.1 YifB family Mg chelatase-like AAA ATPase -
IS178_RS23115 5068201..5069121 - 921 WP_016782670.1 LysR family transcriptional regulator -
IS178_RS23120 5069274..5070674 + 1401 WP_016782671.1 NorM family multidrug efflux MATE transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10437.11 Da        Isoelectric Point: 10.0073

>T180908 WP_029611627.1 NZ_CP064354:c5066521-5066243 [Pseudomonas fragi]
MIVSFKCNRTERLYRSGKTRLWSDILNVIERKLTMLDAASVLTDLASPPGNRLEALGGARKGQYSIRINAQWRICFIWGA
KGPEAVEIVDYH

Download         Length: 279 bp

>T180908 NZ_CP085790:c4576-4220 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGTACAGCAAGATGAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ACATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCATTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAACT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11136.88 Da        Isoelectric Point: 7.2438

>AT180908 WP_016782667.1 NZ_CP064354:c5066235-5065930 [Pseudomonas fragi]
MIKNGMRPVHPGEVLKEEYLEPLSLSSAALARALGVSTPTVNDIVLQRRGVSADMALRLSVCLGTTPEFWLNLQTTYDLR
KAEIDRGAAIREQVQPIHHCA

Download         Length: 306 bp

>AT180908 NZ_CP085790:c4227-3925 [Acinetobacter baumannii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCGTCATTGTCAGCAATCGAAAATCGTGGTTATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTTAATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References