Detailed information of TA system TA180844

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 458038..458744
• Replicon: chromosome
• Accession: NZ_CP064332
• Organism: Xylella fastidiosa subsp. fastidiosa strain Bakersfield-11

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: Q87EE2
• Locus tag: IUD21_RS01880
• Protein ID: WP_004090696.1
• Coordinates: 458038..458340 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q87EE1
• Locus tag: IUD21_RS01885
• Protein ID: WP_004090697.1
• Coordinates: 458343..458744 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUD21_RS01845	453807..454526	-	720	Protein_345	phage late control D family protein	-
IUD21_RS01850	454426..455397	-	972	WP_011097609.1	hypothetical protein	-
IUD21_RS01855	455405..455962	-	558	WP_011097610.1	phage tail protein I	-
IUD21_RS01860	455955..456847	-	893	Protein_348	baseplate J/gp47 family protein	-
IUD21_RS01865	456847..457185	-	339	WP_004090694.1	GPW/gp25 family protein	-
IUD21_RS01870	457383..457664	+	282	WP_004090695.1	type II toxin-antitoxin system RelE/ParE family toxin	-
IUD21_RS01875	457675..457950	+	276	WP_004085172.1	HigA family addiction module antidote protein	-
IUD21_RS01880	458038..458340	+	303	WP_004090696.1	type II toxin-antitoxin system MqsR family toxin	Toxin
IUD21_RS01885	458343..458744	+	402	WP_004090697.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
IUD21_RS01890	458813..459400	-	588	WP_011097612.1	phage baseplate assembly protein V	-
IUD21_RS01895	459397..459939	-	543	WP_011097613.1	hypothetical protein	-
IUD21_RS01900	459915..460436	-	522	WP_011097614.1	hypothetical protein	-
IUD21_RS01905	460433..460756	-	324	WP_011097935.1	hypothetical protein	-
IUD21_RS01910	460756..461016	-	261	WP_011097616.1	hypothetical protein	-
IUD21_RS01915	461034..462908	-	1875	WP_011097617.1	phage major capsid protein	-
IUD21_RS01920	462905..463537	-	633	WP_011097618.1	phage portal protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	445982..468814	22832

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-99)

Antitoxin

• Cro/C1-type helix-turn-helix domain (74-127)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10948.71 Da
• Isoelectric Point: 8.0251

>T180844 WP_004090696.1 NZ_CP064332:458038-458340 [Xylella fastidiosa subsp. fastidiosa]
MEKGTSHYKLPVVKALVKAGKVRATATAYQGARELGIKDLTGMCTVVLALTSADFYKSMTTYADHTVFQDVYHAKTASGD
EVYLKLTVIDDVLIVSFKEL

Nucleotide

• Length: 303 bp

>T180844 NZ_CP085753:c1856917-1856501 [Enterobacter hormaechei]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14944.02 Da
• Isoelectric Point: 7.1650

>AT180844 WP_004090697.1 NZ_CP064332:458343-458744 [Xylella fastidiosa subsp. fastidiosa]
MRCPCCGAAELIHDTRDMLYTYKSETTSIPTVTGDFCPACGEVVLDREHGDRYSELVGLFQRQVNSAYVDPGYITKVRRK
LDLDQRQAAELFGGGVNAFSRYENGKTKPPLSLVKLFKLLDRHPDLLNEVKSS

Nucleotide

• Length: 402 bp

>AT180844 NZ_CP085753:c1857144-1856914 [Enterobacter hormaechei]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: Q87EE2

Antitoxin

• AlphaFold DB: Q87EE1