Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1400471..1401035 Replicon chromosome
Accession NZ_CP064311
Organism Lacticaseibacillus paracasei subsp. tolerans strain MGB0625

Toxin (Protein)


Gene name yafQ Uniprot ID A0A6G9EML4
Locus tag LacP0625_RS06880 Protein ID WP_014951859.1
Coordinates 1400733..1401035 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID K6SLT0
Locus tag LacP0625_RS06875 Protein ID WP_003570051.1
Coordinates 1400471..1400740 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LacP0625_RS06845 1395812..1396699 - 888 WP_016385537.1 ABC transporter ATP-binding protein -
LacP0625_RS06850 1396896..1398122 - 1227 WP_003574766.1 hypothetical protein -
LacP0625_RS06855 1398320..1398724 + 405 WP_003574768.1 MerR family transcriptional regulator -
LacP0625_RS06860 1398717..1399043 + 327 WP_003658351.1 YrdB family protein -
LacP0625_RS06865 1399105..1399399 + 295 Protein_1326 hypothetical protein -
LacP0625_RS06870 1399444..1400097 + 654 WP_123022823.1 GNAT family N-acetyltransferase -
LacP0625_RS06875 1400471..1400740 + 270 WP_003570051.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LacP0625_RS06880 1400733..1401035 + 303 WP_014951859.1 type II toxin-antitoxin system YafQ family toxin Toxin
LacP0625_RS06885 1401374..1401517 + 144 WP_003574774.1 hypothetical protein -
LacP0625_RS06890 1401744..1402331 + 588 WP_003574776.1 hypothetical protein -
LacP0625_RS06895 1402567..1404744 + 2178 WP_016385304.1 RNA-binding transcriptional accessory protein -
LacP0625_RS06900 1404919..1405356 - 438 WP_016385305.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-98)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11441.27 Da        Isoelectric Point: 10.2818

>T180801 WP_014951859.1 NZ_CP064311:1400733-1401035 [Lacticaseibacillus paracasei subsp. tolerans]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELHVDGPRGDWLLIYKIK
QQDLILTLVRTGSHHNLLGK

Download         Length: 303 bp

>T180801 NZ_CP085740:828064-828474 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9982.68 Da        Isoelectric Point: 7.2026

>AT180801 WP_003570051.1 NZ_CP064311:1400471-1400740 [Lacticaseibacillus paracasei subsp. tolerans]
MAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV

Download         Length: 270 bp

>AT180801 NZ_CP085740:827817-828083 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G9EML4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2BRK6

References