Detailed information of TA system TA180449

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 224027..224559
• Replicon: chromosome
• Accession: NZ_CP064192
• Organism: Saccharothrix sp. 6-C

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: IOD16_RS01080
• Protein ID: WP_201438549.1
• Coordinates: 224305..224559 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: IOD16_RS01075
• Protein ID: WP_201438548.1
• Coordinates: 224027..224308 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IOD16_RS01050	219245..220183	+	939	WP_201438546.1	DNA recombination protein RmuC	-
IOD16_RS01055	220233..221030	+	798	WP_201441131.1	hypothetical protein	-
IOD16_RS01060	221035..221469	-	435	WP_201441132.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
IOD16_RS01065	221529..222797	-	1269	WP_201438547.1	helix-turn-helix domain-containing protein	-
IOD16_RS01070	222878..223957	+	1080	WP_123744098.1	redox-regulated ATPase YchF	-
IOD16_RS01075	224027..224308	+	282	WP_201438548.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
IOD16_RS01080	224305..224559	+	255	WP_201438549.1	Txe/YoeB family addiction module toxin	Toxin
IOD16_RS01085	224915..226126	+	1212	WP_201438550.1	mannosyltransferase	-
IOD16_RS01090	226082..226375	-	294	WP_201438551.1	4a-hydroxytetrahydrobiopterin dehydratase	-
IOD16_RS01095	226513..227547	+	1035	WP_201441133.1	thiamine ABC transporter substrate-binding protein	-
IOD16_RS01100	227523..229148	+	1626	WP_201438552.1	iron ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-64)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10025.47 Da
• Isoelectric Point: 6.7252

>T180449 WP_201438549.1 NZ_CP064192:224305-224559 [Saccharothrix sp. 6-C]
VRLVFEEQGWEDYTSWLKNDRKMLARVNKLIEDALRDPFTGIGKPEPLKYHLPGAWSRRIDDEHRLVYLVVDDQVIVLAA
RYHY

Nucleotide

• Length: 255 bp

>T180449 NZ_CP085392:255980-256330 [Cytobacillus oceanisediminis]
TTGATTGTCAAACGTGGTGACGTTTATTTTGCAGACCTATCCCCAGTTGTTGGTTCAGAACAAGGCGGCGTCCGTCCAGT
GCTTGTCATCCAAAACGACATCGGGAATCGGTTTAGTCCCACAGTAATTGTTGCAGCAATCACAGCTCAGATTCAAAAAG
CGAAGCTGCCTACTCACGTTGAAATTGATGCGAAGCGTTATGGTTTTGAAAGGGATTCGGTCATCTTATTAGAACAGATT
CGTACAATTGATAAACAACGCTTAACCGATAAAATAACCCATCTCGATGACGAAATGATGGAAAAAGTGGATGAAGCCGT
GCAAATCAGCTTAGGCCTCATCGAATTTTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 9894.15 Da
• Isoelectric Point: 5.1373

>AT180449 WP_201438548.1 NZ_CP064192:224027-224308 [Saccharothrix sp. 6-C]
MSITASEARKALFPLIKQVNEDHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPANARRLLKAYENALGGVGLSAREL
IDSEAADAKAGAE

Nucleotide

• Length: 282 bp

>AT180449 NZ_CP085392:255694-255975 [Cytobacillus oceanisediminis]
GTGTCTGATTCCAGCACAACAACAGAGATAATGGTAAAGTTACCGCAGCATCTTTTAACCGAGTTAGACGGATTTGCAAA
ACAGGAAAACGTTAACCGGAGCGAATTCATTTATCAGGCAACCAAAATGTATTTGCGCGAACGCAAAAAGAGACAAATTC
GCGAGTCCATGAGACGAGGCTACATGGAGATGGCGAAAATAAATTTGACGATTGCATCTGAAGCATTTCAAGCGGAATAC
GAGGCAGAACACACAGTTGAACGTCTAGTAAGCGGAGGATAA