Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 224027..224559 Replicon chromosome
Accession NZ_CP064192
Organism Saccharothrix sp. 6-C

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag IOD16_RS01080 Protein ID WP_201438549.1
Coordinates 224305..224559 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag IOD16_RS01075 Protein ID WP_201438548.1
Coordinates 224027..224308 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD16_RS01050 219245..220183 + 939 WP_201438546.1 DNA recombination protein RmuC -
IOD16_RS01055 220233..221030 + 798 WP_201441131.1 hypothetical protein -
IOD16_RS01060 221035..221469 - 435 WP_201441132.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
IOD16_RS01065 221529..222797 - 1269 WP_201438547.1 helix-turn-helix domain-containing protein -
IOD16_RS01070 222878..223957 + 1080 WP_123744098.1 redox-regulated ATPase YchF -
IOD16_RS01075 224027..224308 + 282 WP_201438548.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
IOD16_RS01080 224305..224559 + 255 WP_201438549.1 Txe/YoeB family addiction module toxin Toxin
IOD16_RS01085 224915..226126 + 1212 WP_201438550.1 mannosyltransferase -
IOD16_RS01090 226082..226375 - 294 WP_201438551.1 4a-hydroxytetrahydrobiopterin dehydratase -
IOD16_RS01095 226513..227547 + 1035 WP_201441133.1 thiamine ABC transporter substrate-binding protein -
IOD16_RS01100 227523..229148 + 1626 WP_201438552.1 iron ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-64)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10025.47 Da        Isoelectric Point: 6.7252

>T180449 WP_201438549.1 NZ_CP064192:224305-224559 [Saccharothrix sp. 6-C]
VRLVFEEQGWEDYTSWLKNDRKMLARVNKLIEDALRDPFTGIGKPEPLKYHLPGAWSRRIDDEHRLVYLVVDDQVIVLAA
RYHY

Download         Length: 255 bp

>T180449 NZ_CP085392:255980-256330 [Cytobacillus oceanisediminis]
TTGATTGTCAAACGTGGTGACGTTTATTTTGCAGACCTATCCCCAGTTGTTGGTTCAGAACAAGGCGGCGTCCGTCCAGT
GCTTGTCATCCAAAACGACATCGGGAATCGGTTTAGTCCCACAGTAATTGTTGCAGCAATCACAGCTCAGATTCAAAAAG
CGAAGCTGCCTACTCACGTTGAAATTGATGCGAAGCGTTATGGTTTTGAAAGGGATTCGGTCATCTTATTAGAACAGATT
CGTACAATTGATAAACAACGCTTAACCGATAAAATAACCCATCTCGATGACGAAATGATGGAAAAAGTGGATGAAGCCGT
GCAAATCAGCTTAGGCCTCATCGAATTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 9894.15 Da        Isoelectric Point: 5.1373

>AT180449 WP_201438548.1 NZ_CP064192:224027-224308 [Saccharothrix sp. 6-C]
MSITASEARKALFPLIKQVNEDHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPANARRLLKAYENALGGVGLSAREL
IDSEAADAKAGAE

Download         Length: 282 bp

>AT180449 NZ_CP085392:255694-255975 [Cytobacillus oceanisediminis]
GTGTCTGATTCCAGCACAACAACAGAGATAATGGTAAAGTTACCGCAGCATCTTTTAACCGAGTTAGACGGATTTGCAAA
ACAGGAAAACGTTAACCGGAGCGAATTCATTTATCAGGCAACCAAAATGTATTTGCGCGAACGCAAAAAGAGACAAATTC
GCGAGTCCATGAGACGAGGCTACATGGAGATGGCGAAAATAAATTTGACGATTGCATCTGAAGCATTTCAAGCGGAATAC
GAGGCAGAACACACAGTTGAACGTCTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References