Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4380816..4381632 Replicon chromosome
Accession NZ_CP064180
Organism Citrobacter amalonaticus strain CA71

Toxin (Protein)


Gene name yhaV Uniprot ID A0A3S7D6F0
Locus tag ISX58_RS21335 Protein ID WP_042999109.1
Coordinates 4380816..4381292 (-) Length 159 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A3Q8DNJ3
Locus tag ISX58_RS21340 Protein ID WP_042999108.1
Coordinates 4381297..4381632 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISX58_RS21315 4375921..4376664 - 744 WP_044257300.1 molecular chaperone -
ISX58_RS21320 4376707..4379181 - 2475 WP_044257386.1 fimbria/pilus outer membrane usher protein -
ISX58_RS21325 4379245..4379694 - 450 WP_194694281.1 type 1 fimbrial protein -
ISX58_RS21330 4379862..4380392 - 531 WP_042999110.1 type 1 fimbrial protein -
ISX58_RS21335 4380816..4381292 - 477 WP_042999109.1 type II toxin-antitoxin system YhaV family toxin Toxin
ISX58_RS21340 4381297..4381632 - 336 WP_042999108.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
ISX58_RS21345 4381847..4382383 - 537 WP_042999107.1 ferredoxin-type protein NapF -
ISX58_RS21350 4382380..4382976 - 597 WP_042999106.1 molecular chaperone -
ISX58_RS21355 4383021..4383794 - 774 WP_044257303.1 dimethyl sulfoxide reductase anchor subunit -
ISX58_RS21360 4383787..4384413 - 627 WP_044257304.1 dimethylsulfoxide reductase subunit B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(15-110)


Sequences

Toxin        


Download         Length: 159 a.a.        Molecular weight: 18237.84 Da        Isoelectric Point: 8.8956

>T180438 WP_042999109.1 NZ_CP064180:c4381292-4380816 [Citrobacter amalonaticus]
MDFPTWLNGWTIYAHPCFIDQYNALVARVEDLKHRFPDPIVFQKKKETKVLAHLLKSIANITHEPRASVYRPGDSIGKAY
TDWSRAKFGGGRYRLFFRYSLESKIIVIAWVNDEGPLRTYGSKTDAYKIFGKMLDEGNPPDDWLSLLQACQNDGKEHL

Download         Length: 477 bp

>T180438 NZ_CP085344:2449339-2449629 [Cupriavidus sp. MP-37]
ATGAAAGAACCAACCCGCCCTTGGGACTCGGCCGCACAACTGCGCAACGAAACGGAAATCGCCGCCTACCTGGACACCTG
CCTCGCCGAAGCCGGTGACGACGATCGTTTCATTGCCTACGCGCTCGGCGTGGTCGCGCGCGCCCGCGGCATGACGCGGC
TGGCCCGCGAAACCGGCCTGTCGCGCGAAAGCCTTTACCGTTCGCTGTCCGGCGAAGGCAATCCGGAGTTCGGGACCATC
TGGAAGGTGATGCGGGCGCTGGGAATTCGCCTGCATGCGAGCGTCGGCTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12505.83 Da        Isoelectric Point: 4.1876

>AT180438 WP_042999108.1 NZ_CP064180:c4381632-4381297 [Citrobacter amalonaticus]
MFAYVRSEDIAIEADSKLTERHQTTIPASIRDALHLRSGDRIHYTLLSTGEVLLSKYSEATEDGVMRSFLDFLSQDVANN
PQTLKKLDLSRGYELVDGIDVNLDDEISDED

Download         Length: 336 bp

>AT180438 NZ_CP085344:2449035-2449325 [Cupriavidus sp. MP-37]
ATGCTCAGCATCCGCACCACCCAAACGTTTGACCGCTGGTACGCCGCCTTGCGCGACAGCGCTGCCAGGATTCGCATTCA
GGTCCGGATCGACCGCATGCTGAACGGAAATCCGGGCGACGTGAAAGCCCTTGGCGGTGGCATCTGTGAAATGCGGGTGG
ACCATGGTCCCGGCTACCGCATCTATTTTCAGCGATGCGGCGAAGTTCTTGTCATTCTCCTCTGCGGAGGCGACAAGTCG
ACCCAGCACGCTGATATCGGCCGGGGCACGCCACATGGCGGCGAACCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S7D6F0

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q8DNJ3

References