Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2307757..2308319 Replicon chromosome
Accession NZ_CP064180
Organism Citrobacter amalonaticus strain CA71

Toxin (Protein)


Gene name higB Uniprot ID A0A7L6Z3F2
Locus tag ISX58_RS10910 Protein ID WP_044257939.1
Coordinates 2307757..2308035 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ISX58_RS10915 Protein ID WP_043000693.1
Coordinates 2308035..2308319 (+) Length 95 a.a.

Genomic Context

ISX58_RS10895ISX58_RS10900ISX58_RS10905ISX58_RS10910ISX58_RS10915ISX58_RS10890ISX58_RS10920ISX58_RS10925ISX58_RS10930
Location: 2303541..2303684 (144 bp)
Type: Others
Protein ID: WP_042319017.1
Location: 2303856..2305553 (1698 bp)
Type: Others
Protein ID: WP_044257943.1
Location: 2305862..2307577 (1716 bp)
Type: Others
Protein ID: WP_044257940.1
Location: 2307757..2308035 (279 bp)
Type: Toxin
Protein ID: WP_044257939.1
Location: 2308035..2308319 (285 bp)
Type: Antitoxin
Protein ID: WP_043000693.1
Location: 2302882..2303313 (432 bp)
Type: Others
Protein ID: WP_043000697.1
Location: 2308364..2308966 (603 bp)
Type: Others
Protein ID: WP_044257938.1
Location: 2309093..2309749 (657 bp)
Type: Others
Protein ID: WP_043000691.1
Location: 2309742..2310626 (885 bp)
Type: Others
Protein ID: WP_043000690.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ISX58_RS108902302882..2303313-432WP_043000697.1peroxiredoxin OsmC-
ISX58_RS108952303541..2303684+144WP_042319017.1stationary-phase-induced ribosome-associated protein-
ISX58_RS109002303856..2305553+1698WP_044257943.1malate dehydrogenase-
ISX58_RS109052305862..2307577+1716WP_044257940.1ATP-binding cassette domain-containing protein-
ISX58_RS109102307757..2308035+279WP_044257939.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ISX58_RS109152308035..2308319+285WP_043000693.1HigA family addiction module antidote proteinAntitoxin
ISX58_RS109202308364..2308966-603WP_044257938.1inorganic diphosphatase-
ISX58_RS109252309093..2309749-657WP_043000691.1formate dehydrogenase-N subunit gamma-
ISX58_RS109302309742..2310626-885WP_043000690.1formate dehydrogenase subunit beta-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10525.03 Da        Isoelectric Point: 8.1206

>T180428 WP_044257939.1 NZ_CP064180:2307757-2308035 [Citrobacter amalonaticus]
MIMNFRHKGLRDLFLHGKTSGVLAKHVKRLRHRLAVIDAAGCVNDINMPGYRLHPLSGDRDGVWSISVSGNWRMTFEFVN
GDAYILDDEDYH

Download         Length: 279 bp

>T180428 NZ_CP085296:22732-23073 [Enterococcus faecalis]
ATGAGTGACGAAAAGAAATATATTCCTAAAAAGGGCGATATTGTATGGATAGATTTCGATCCTTCAGCTGAAAAAGAAAT
ACAGAAAAGACGTCCAGGTCTAGTAGTTTCTAGATATGAGTTTAATAGAAAGACATTGTTTGCAGTAATTTGTCCCATAA
CTTCTACAATTAAAAATATGCCAACTCGTTATACATTACCTGATGAAATGGAAACTCATGGACAAGTCGTTATTTCCCAA
TTAAAATCTTTAGACTTTGCAGAAAGAAAGTTAAGCCAAATAGAACATTTACCATTAAAGGATATGGCTAAAATAGATCA
AATCATTGAATACATTTTTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10370.07 Da        Isoelectric Point: 10.2982

>AT180428 WP_043000693.1 NZ_CP064180:2308035-2308319 [Citrobacter amalonaticus]
MKMANHPRPGDIIQEALDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQNTWSLAQAQ
KSVDVSRLRRLAVQ

Download         Length: 285 bp

>AT180428 NZ_CP085296:22502-22732 [Enterococcus faecalis]
ATGTTAACCACAAAATCTAGAAAACAAGGAAGTTCTGTAGTATTGACATTACCATCTAATAACGGACAGAAACCAAAAGC
AGACCAAGAATATATAGTGATGTATTCTGATGATGGGACAATTACGTTAGTCCCTAAATTACAAGACCCATTTAGTGGTG
GATCAGAAGGGGAGTACTACGAAAAAGATGAATGGCATGACATTGAACCTGGAGGGAGAGAATTATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7L6Z3F2

Antitoxin

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Source
ID
Structure
No matching records found

References