Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4842202..4842848 Replicon chromosome
Accession NZ_CP064174
Organism Klebsiella pneumoniae strain 19110124

Toxin (Protein)


Gene name higB Uniprot ID W8UNE1
Locus tag ISU39_RS23905 Protein ID WP_002920560.1
Coordinates 4842501..4842848 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag ISU39_RS23900 Protein ID WP_002920557.1
Coordinates 4842202..4842501 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU39_RS23880 4838408..4839166 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
ISU39_RS23885 4839216..4840046 - 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
ISU39_RS23890 4840097..4840426 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
ISU39_RS23895 4840631..4842139 + 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
ISU39_RS23900 4842202..4842501 - 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
ISU39_RS23905 4842501..4842848 - 348 WP_002920560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ISU39_RS23910 4843024..4845471 - 2448 WP_002920561.1 glycogen phosphorylase -
ISU39_RS23915 4845489..4846922 - 1434 WP_002920564.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13502.56 Da        Isoelectric Point: 6.2300

>T180421 WP_002920560.1 NZ_CP064174:c4842848-4842501 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRACFAFDPLRKAI
VLCVGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T180421 NZ_CP085294:361149-361292 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT180421 WP_002920557.1 NZ_CP064174:c4842501-4842202 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT180421 NZ_CP085294:c361409-361225 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGATATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CBY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References