Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 2380890..2381302 Replicon chromosome
Accession NZ_CP064167
Organism Escherichia coli O157:H7 strain Wll001

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag IMX21_RS11895 Protein ID WP_000132630.1
Coordinates 2380961..2381302 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 2380890..2380966 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMX21_RS11885 2377517..2378986 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
IMX21_RS11890 2378986..2380740 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- 2380890..2380966 - 77 NuclAT_15 - Antitoxin
- 2380890..2380966 - 77 NuclAT_15 - Antitoxin
- 2380890..2380966 - 77 NuclAT_15 - Antitoxin
- 2380890..2380966 - 77 NuclAT_15 - Antitoxin
- 2380890..2380966 - 77 NuclAT_16 - Antitoxin
- 2380890..2380966 - 77 NuclAT_16 - Antitoxin
- 2380890..2380966 - 77 NuclAT_16 - Antitoxin
- 2380890..2380966 - 77 NuclAT_16 - Antitoxin
IMX21_RS11895 2380961..2381302 + 342 WP_000132630.1 endoribonuclease SymE Toxin
IMX21_RS11900 2381349..2382512 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
IMX21_RS11905 2382560..2383441 - 882 WP_001304007.1 DUF262 domain-containing protein -
IMX21_RS11910 2383538..2383702 - 165 WP_000394274.1 DUF1127 domain-containing protein -
IMX21_RS11915 2383879..2385291 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
IMX21_RS11920 2385534..2385734 - 201 WP_001310455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 2373089..2394328 21239


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T180389 WP_000132630.1 NZ_CP064167:2380961-2381302 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T180389 NZ_CP085202:c4394753-4394646 [Shigella flexneri]
ATGACGTTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 77 bp

>AT180389 NZ_CP064167:c2380966-2380890 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References