Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 2035668..2036207 Replicon chromosome
Accession NZ_CP064167
Organism Escherichia coli O157:H7 strain Wll001

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag IMX21_RS10330 Protein ID WP_001303998.1
Coordinates 2035947..2036207 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID C3TP07
Locus tag IMX21_RS10325 Protein ID WP_000729705.1
Coordinates 2035668..2035928 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMX21_RS10305 2031422..2032207 - 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -
IMX21_RS10310 2032152..2033891 + 1740 WP_009625779.1 flagellar biosynthesis protein FlhA -
IMX21_RS10315 2034036..2034533 - 498 Protein_2022 REP-associated tyrosine transposase RayT -
IMX21_RS10320 2034709..2035482 - 774 WP_000543891.1 C40 family peptidase -
IMX21_RS10325 2035668..2035928 + 261 WP_000729705.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
IMX21_RS10330 2035947..2036207 + 261 WP_001303998.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
IMX21_RS10335 2036363..2037103 + 741 WP_001225679.1 murein L,D-transpeptidase -
IMX21_RS10340 2037074..2037841 - 768 WP_001301698.1 class II glutamine amidotransferase -
IMX21_RS10345 2037946..2038524 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10026.71 Da        Isoelectric Point: 10.3188

>T180387 WP_001303998.1 NZ_CP064167:2035947-2036207 [Escherichia coli O157:H7]
MNSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLRFERTGT
HAALFG

Download         Length: 261 bp

>T180387 NZ_CP085202:c4393787-4393680 [Shigella flexneri]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9377.74 Da        Isoelectric Point: 5.0758

>AT180387 WP_000729705.1 NZ_CP064167:2035668-2035928 [Escherichia coli O157:H7]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGV

Download         Length: 261 bp

>AT180387 NZ_CP085202:4393844-4393899 [Shigella flexneri]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References