Detailed information of TA system TA180348

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 3428232..3428926
• Replicon: chromosome
• Accession: NZ_CP064128
• Organism: Yersinia pestis strain M2086

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A0A0E1NW62
• Locus tag: ISU65_RS15350
• Protein ID: WP_002214787.1
• Coordinates: 3428232..3428528 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q666X1
• Locus tag: ISU65_RS15355
• Protein ID: WP_002209924.1
• Coordinates: 3428528..3428926 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISU65_RS15325	3424605..3425627	+	1023	WP_000255944.1	IS21-like element IS100 family transposase	-
ISU65_RS15330	3425627..3426406	+	780	WP_001297096.1	IS21-like element IS100kyp family helper ATPase IstB	-
ISU65_RS15335	3426600..3426785	-	186	WP_002209928.1	hypothetical protein	-
ISU65_RS15340	3427383..3427643	+	261	WP_002214785.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ISU65_RS15345	3427706..3428068	+	363	WP_002209925.1	helix-turn-helix domain-containing protein	-
ISU65_RS15350	3428232..3428528	+	297	WP_002214787.1	type II toxin-antitoxin system MqsR family toxin	Toxin
ISU65_RS15355	3428528..3428926	+	399	WP_002209924.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
ISU65_RS15360	3429326..3431617	-	2292	WP_002209923.1	toprim domain-containing protein	-
ISU65_RS15365	3431917..3432243	+	327	WP_002209922.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ISU65_RS15370	3432236..3432388	+	153	WP_002209921.1	hypothetical protein	-
ISU65_RS15375	3432402..3432602	-	201	WP_002209920.1	AlpA family transcriptional regulator	-
ISU65_RS15380	3432784..3433116	-	333	WP_002214791.1	hypothetical protein	-
ISU65_RS15385	3433122..3433358	-	237	WP_002214792.1	hypothetical protein	-
ISU65_RS15390	3433371..3433736	-	366	WP_002209919.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3420212..3453214	33002

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11319.12 Da
• Isoelectric Point: 7.8810

>T180348 WP_002214787.1 NZ_CP064128:3428232-3428528 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Nucleotide

• Length: 297 bp

>T180348 NZ_CP085188:1837531-1837782 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14657.17 Da
• Isoelectric Point: 8.4923

>AT180348 WP_002209924.1 NZ_CP064128:3428528-3428926 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Nucleotide

• Length: 399 bp

>AT180348 NZ_CP085188:1837779-1838033 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Toxin

• AlphaFold DB: A0A0E1NW62

Antitoxin

• AlphaFold DB: Q666X1