Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2929925..2930619 Replicon chromosome
Accession NZ_CP064127
Organism Yersinia pestis strain C-830

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag ISU64_RS13275 Protein ID WP_002214787.1
Coordinates 2930323..2930619 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag ISU64_RS13270 Protein ID WP_002209924.1
Coordinates 2929925..2930323 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU64_RS13235 2925115..2925480 + 366 WP_002209919.1 hypothetical protein -
ISU64_RS13240 2925493..2925729 + 237 WP_002214792.1 hypothetical protein -
ISU64_RS13245 2925735..2926067 + 333 WP_002214791.1 hypothetical protein -
ISU64_RS13250 2926249..2926449 + 201 WP_002209920.1 AlpA family transcriptional regulator -
ISU64_RS13255 2926463..2926615 - 153 WP_002209921.1 hypothetical protein -
ISU64_RS13260 2926608..2926934 - 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
ISU64_RS13265 2927234..2929525 + 2292 WP_002209923.1 toprim domain-containing protein -
ISU64_RS13270 2929925..2930323 - 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
ISU64_RS13275 2930323..2930619 - 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
ISU64_RS13280 2930783..2931145 - 363 WP_002209925.1 helix-turn-helix domain-containing protein -
ISU64_RS13285 2931208..2931468 - 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
ISU64_RS13290 2932066..2932251 + 186 WP_002209928.1 hypothetical protein -
ISU64_RS13295 2932333..2933547 - 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
ISU64_RS13305 2933980..2935497 - 1518 WP_002209930.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T180335 WP_002214787.1 NZ_CP064127:c2930619-2930323 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T180335 NZ_CP085184:33905-34426 [Escherichia coli]
GTGAGCAATACAACGATAGAGATTTTCTCTGGAGAGAAAGATTATGATCTAAACGGTTTTGATTGCGGCGAAGAGTCACT
AAACGCCTTTTTAGCCAACCACTTAAAAAGGCAGCATGAGGGAAAAATTCTTCGTGCTTATGTGCTTTGCACTCAAGAAG
AAAGGCCAAAAGTGTTAGGATATTACACTTTGTCAGGTAGTTGTTTTGAAAAGGAGTCCTTACCTTCAAGAAGCAAACAA
AAGAAGGTTCCTTATCGGAATGTTCCAAGTGTTACTTTGGGTAGGCTGGCTTTGGACAAGTCCCTTCAAGGTCAAGGATT
TGGCTCAATGCTTGTAACACATGCAATGCGCGTTGTGTACAATGCATCTCTTGCTGTAGGCATTCATGGACTTTTCGTTG
AGGCGTTAAATGACAAAGCCAAGGCGTTTTATAAAAGTTTAGGCTTTATCCAGCTGGTTGGTAACAACGAGCGTTCTTTG
TTCTATCCTACAAAATCTATCGAAAAATTGTTCGAAGAATAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT180335 WP_002209924.1 NZ_CP064127:c2930323-2929925 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT180335 NZ_CP085184:33628-33897 [Escherichia coli]
ATGTCAGCACTAAAAAAGCAGCGCATCGATTTGAGATTAACCGATGACGATAAAAGCATCATCGAGGAAGCTGCCGCAAT
GTCTAACCAGAGCATTACTCAGTTTATGGTTAGCAGTGCATCTGAACGTGCCGTGAAAGTTATAGAGCAACACCGTAGAC
TAGTTCTGAATGAAGAATCCTGGAATCTGGTTATGGACGCTATAAGCAATCCTCCGGCACCGAACGACAAGCTGAAACGA
GCTGCTGATCGTCTGAAAAGCATGGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References