Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 937197..937891 Replicon chromosome
Accession NZ_CP064126
Organism Yersinia pestis strain I-1252

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag ISU63_RS04115 Protein ID WP_002214787.1
Coordinates 937197..937493 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag ISU63_RS04120 Protein ID WP_002209924.1
Coordinates 937493..937891 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU63_RS04085 932319..933836 + 1518 WP_002209930.1 lysine--tRNA ligase -
ISU63_RS04095 934269..935483 + 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
ISU63_RS04100 935565..935750 - 186 WP_002209928.1 hypothetical protein -
ISU63_RS04105 936348..936608 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
ISU63_RS04110 936671..937033 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
ISU63_RS04115 937197..937493 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
ISU63_RS04120 937493..937891 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
ISU63_RS04125 938291..940582 - 2292 WP_002209923.1 toprim domain-containing protein -
ISU63_RS04130 940882..941208 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
ISU63_RS04135 941201..941353 + 153 WP_002209921.1 hypothetical protein -
ISU63_RS04140 941367..941567 - 201 WP_002209920.1 AlpA family transcriptional regulator -
ISU63_RS04145 941749..942081 - 333 WP_002214791.1 hypothetical protein -
ISU63_RS04150 942087..942323 - 237 WP_002214792.1 hypothetical protein -
ISU63_RS04155 942336..942701 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T180312 WP_002214787.1 NZ_CP064126:937197-937493 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T180312 NZ_CP085169:c203286-203035 [Sulfitobacter sp. DSM 110093]
ATGGATGTTATGACCTATTCAGATGCACGAGCTCACCTGAAGGACGTCATGGATCGTGCGATCAATGATAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAAGTGAGTCCGTTGTGGTCGTATCCTTGGACACCTGGAACGCCGTTAACGAGACGTTGCACC
TCTTGTCCACACCGAACAACGCATCCCGCTTACGCGCATCGATCGCGCAACTCGATGCTGGAACTGGCAATGAGCGTGAC
CTGGCCGAGTGA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT180312 WP_002209924.1 NZ_CP064126:937493-937891 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT180312 NZ_CP085169:c203038-202772 [Sulfitobacter sp. DSM 110093]
GTGAAGCTGGTTTTCTCTGAACAGGCTTGGGAAGACTATCAACACTGGGTCAGTACCAATGACAAGGTGCATGAGCGGAT
CAACGAGCTGATCAAACAGTGCAAGCGGACCCCTTTAAAAGGGACCGGCAAGCCGGAACCTTTGAAAGGGGATCTGACCG
GCTGGTGGTCACGGCGAATTTCTCAGGAAGATCGAATGGTCTACCGGGTCAAGGGAAGGGGCGACGGTCAAAGCTTAGAG
ATTGCGCAACTGCGGTTCCATTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References