Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3458038..3458732 Replicon chromosome
Accession NZ_CP064125
Organism Yersinia pestis strain M2085

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag ISU62_RS15465 Protein ID WP_002214787.1
Coordinates 3458436..3458732 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag ISU62_RS15460 Protein ID WP_002209924.1
Coordinates 3458038..3458436 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU62_RS15425 3453228..3453593 + 366 WP_002209919.1 hypothetical protein -
ISU62_RS15430 3453606..3453842 + 237 WP_002214792.1 hypothetical protein -
ISU62_RS15435 3453848..3454180 + 333 WP_002214791.1 hypothetical protein -
ISU62_RS15440 3454362..3454562 + 201 WP_002209920.1 AlpA family transcriptional regulator -
ISU62_RS15445 3454576..3454728 - 153 WP_002209921.1 hypothetical protein -
ISU62_RS15450 3454721..3455047 - 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
ISU62_RS15455 3455347..3457638 + 2292 WP_002209923.1 toprim domain-containing protein -
ISU62_RS15460 3458038..3458436 - 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
ISU62_RS15465 3458436..3458732 - 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
ISU62_RS15470 3458896..3459258 - 363 WP_002209925.1 helix-turn-helix domain-containing protein -
ISU62_RS15475 3459321..3459581 - 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
ISU62_RS15480 3460179..3460364 + 186 WP_002209928.1 hypothetical protein -
ISU62_RS15485 3460446..3461660 - 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
ISU62_RS15495 3462093..3463610 - 1518 WP_002209930.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T180309 WP_002214787.1 NZ_CP064125:c3458732-3458436 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T180309 NZ_CP085168:c258356-258105 [Sulfitobacter sp. DSM 110093]
ATGGATGTTATGACCTATTCAGATGCACGAGCTCACCTGAAGGACGTCATGGATCGTGCGATCAATGATAAGCAAGAAGT
TGTTGTGACGCGCAAAAAAAGTGAGTCCGTTGTGGTCGTATCCTTGGACACCTGGAACGCCGTTAACGAGACGTTGCACC
TCTTGTCCACACCGAACAACGCATCCCGCTTACGCGCATCGATCGCGCAACTCGATGCTGGAACTGGCAATGAGCGTGAC
CTGGCCGAGTGA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT180309 WP_002209924.1 NZ_CP064125:c3458436-3458038 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT180309 NZ_CP085168:c258108-257842 [Sulfitobacter sp. DSM 110093]
GTGAAGCTGGTTTTCTCTGAACAGGCTTGGGAAGACTATCAACACTGGGTCAGTACCAATGACAAGGTGCATGAGCGGAT
CAACGAGCTGATCAAACAGTGCAAGCGGACCCCTTTAAAAGGGACCGGCAAGCCGGAACCTTTGAAAGGGGATCTGACCG
GCTGGTGGTCACGGCGAATTTCTCAGGAAGATCGAATGGTCTACCGGGTCAAGGGAAGGGGCGACGGTCAAAGCTTAGAG
ATTGCGCAACTGCGGTTCCATTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References