Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3649232..3649926 Replicon chromosome
Accession NZ_CP064124
Organism Yersinia pestis strain M-1974

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag ISU61_RS16435 Protein ID WP_002214787.1
Coordinates 3649630..3649926 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag ISU61_RS16430 Protein ID WP_002209924.1
Coordinates 3649232..3649630 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU61_RS16395 3644422..3644787 + 366 WP_002209919.1 hypothetical protein -
ISU61_RS16400 3644800..3645036 + 237 WP_002214792.1 hypothetical protein -
ISU61_RS16405 3645042..3645374 + 333 WP_002214791.1 hypothetical protein -
ISU61_RS16410 3645556..3645756 + 201 WP_002209920.1 AlpA family transcriptional regulator -
ISU61_RS16415 3645770..3645922 - 153 WP_002209921.1 hypothetical protein -
ISU61_RS16420 3645915..3646241 - 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
ISU61_RS16425 3646541..3648832 + 2292 WP_002209923.1 toprim domain-containing protein -
ISU61_RS16430 3649232..3649630 - 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
ISU61_RS16435 3649630..3649926 - 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
ISU61_RS16440 3650090..3650452 - 363 WP_002209925.1 helix-turn-helix domain-containing protein -
ISU61_RS16445 3650515..3650775 - 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
ISU61_RS16450 3651373..3651567 + 195 WP_042659217.1 hypothetical protein -
ISU61_RS16455 3651623..3652837 - 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
ISU61_RS16465 3653270..3654787 - 1518 WP_002209930.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T180296 WP_002214787.1 NZ_CP064124:c3649926-3649630 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T180296 NZ_CP085143:c3535691-3535509 [Halomonas sp. NyZ770]
GTGAAAAGCAAGGATGTCATCAAGGAGATGGAAGCTGATGGATGGTATCTAGATCGTGTTAGTGGGAGCCATCACGTATT
CAAGCACCCTACCAAGCTCGGCAGTGTGCCCGTGCCTCATCCGAAAAAGGATTTGCCTAAGGGCACCATCCACAATATCA
GAAAACTTGCGGGGCTCAGGTAG

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT180296 WP_002209924.1 NZ_CP064124:c3649630-3649232 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT180296 NZ_CP085143:c3535485-3535081 [Halomonas sp. NyZ770]
ATGCAATATCCGGTTGCTATCGAATGGGGCGATGAACACACCGCCACCGGTATCGTCATTCCGGACATTCCCGGTGCTGT
GACAGCGGGTGACACGACCGAACATGCTTATGAAATGGCAGTGGAAGTGGCTCATATCCAGTTGGAAGAATTAGCCAACG
AGAATAAAGATATTCCCATGCCGCGCAGCATTGCGGAGCATCGCCAAAATCCAGAATTTGAAGGGTGCGGCTGGGGGATT
ATTGATATTGATATCACGCCCTACCTCGGCAAAACCGAAAAGGTGAATGTGACGCTGCCAGGTCACGTCATTCGTCAGAT
CGACCAATACGTGACCACCCACGGTATTAAAAGTCGTTCTGCGTTCATTGCCTCGGCGGCATTGGAAAAGCTGAACCACG
CGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References