Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3330027..3330721 Replicon chromosome
Accession NZ_CP064123
Organism Yersinia pestis strain M2029

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag ISU60_RS14795 Protein ID WP_002214787.1
Coordinates 3330027..3330323 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag ISU60_RS14800 Protein ID WP_002209924.1
Coordinates 3330323..3330721 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU60_RS14765 3325149..3326666 + 1518 WP_002209930.1 lysine--tRNA ligase -
ISU60_RS14775 3327099..3328313 + 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
ISU60_RS14780 3328395..3328580 - 186 WP_002209928.1 hypothetical protein -
ISU60_RS14785 3329178..3329438 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
ISU60_RS14790 3329501..3329863 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
ISU60_RS14795 3330027..3330323 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
ISU60_RS14800 3330323..3330721 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
ISU60_RS14805 3331121..3333412 - 2292 WP_002209923.1 toprim domain-containing protein -
ISU60_RS14810 3333712..3334038 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
ISU60_RS14815 3334031..3334183 + 153 WP_002209921.1 hypothetical protein -
ISU60_RS14820 3334197..3334397 - 201 WP_002209920.1 AlpA family transcriptional regulator -
ISU60_RS14825 3334579..3334911 - 333 WP_002214791.1 hypothetical protein -
ISU60_RS14830 3334917..3335153 - 237 WP_002214792.1 hypothetical protein -
ISU60_RS14835 3335166..3335531 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T180284 WP_002214787.1 NZ_CP064123:3330027-3330323 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T180284 NZ_CP085096:1851779-1852030 [Aggregatibacter actinomycetemcomitans]
ATGAATGTAATAAGTTATTCTGCGTTTCGTGCAGAATTGGCAACCACACTTGATCAGGTGGTAGCAGATCATAGCCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTCGCAGCTTACGAAGAAACGGCTTATT
TATTACGCAGCCCCAAAAATAGAGAGCGTTTATTAGCCTCTATTGACCAGCTCAATTCAGGTAAAATCATCGAACGGGAA
CTCCAGGAATGA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT180284 WP_002209924.1 NZ_CP064123:3330323-3330721 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT180284 NZ_CP085096:1852027-1852281 [Aggregatibacter actinomycetemcomitans]
ATGATTTTAGCTTGGACGGAAACCGCCTGGGAAGATTATCTTTATTGGCAGCAAGTTGATAAAAAGACGTTGTTGCGCAT
TAATAAACTTATCCAAAATATTACCAGATCACCTTTCGAAGGCTTAGGCAATCCTGAACCTTTAAAACATCAGTTATCCG
GGTTTTGGTCTAGAAGAATAGATAAAGAGCATCGTCTTGTATACCAAGTATCGGATAGCCATTTAACGATTATTCAATGC
CGCTATCACTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References