Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 976643..977337 Replicon chromosome
Accession NZ_CP064122
Organism Yersinia pestis strain M-1770

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag ISU59_RS04080 Protein ID WP_002214787.1
Coordinates 976643..976939 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag ISU59_RS04085 Protein ID WP_002209924.1
Coordinates 976939..977337 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU59_RS04055 973016..974038 + 1023 WP_000255944.1 IS21-like element IS100 family transposase -
ISU59_RS04060 974038..974817 + 780 WP_001297096.1 IS21-like element IS100kyp family helper ATPase IstB -
ISU59_RS04065 975011..975196 - 186 WP_002209928.1 hypothetical protein -
ISU59_RS04070 975794..976054 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
ISU59_RS04075 976117..976479 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
ISU59_RS04080 976643..976939 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
ISU59_RS04085 976939..977337 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
ISU59_RS04090 977737..980028 - 2292 WP_002209923.1 toprim domain-containing protein -
ISU59_RS04095 980328..980654 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
ISU59_RS04100 980647..980799 + 153 WP_002209921.1 hypothetical protein -
ISU59_RS04105 980813..981013 - 201 WP_002209920.1 AlpA family transcriptional regulator -
ISU59_RS04110 981195..981527 - 333 WP_002214791.1 hypothetical protein -
ISU59_RS04115 981533..981769 - 237 WP_002214792.1 hypothetical protein -
ISU59_RS04120 981782..982147 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T180260 WP_002214787.1 NZ_CP064122:976643-976939 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T180260 NZ_CP085094:1276342-1276692 [Aggregatibacter actinomycetemcomitans]
ATGTGGGCGGTGATTTTAACGGAACGATTTGAAACTTGGTTAAATCAACAGCCGATAAAAACGCAGGAATGTGTTTTGGC
AAACTTGGTACGGTTGGAACATTTTGGTCCGAATTTAGCCCGTCCTTATGTAGATAGCGTAGCAGGGTCAATTCATAGCA
ACATGAAAGAACTACGCGTTCAGCATTCGGGAAGAGCAATTCGACTCTTTTTTGCTTTTGATCCAAAGCGTAGAGCCATT
GTTTTATGTGGTGGAGATAAAGGCAATGACAAGCGGTTTTACCGTACGATGATTAGAATTGCAGATCAAGAATTGAATCA
TTATTTGGCAACCATGGAGCAAACAAAATGA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT180260 WP_002209924.1 NZ_CP064122:976939-977337 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT180260 NZ_CP085094:1276689-1276988 [Aggregatibacter actinomycetemcomitans]
ATGAAAACATTACAACAAGTTATTGATGAACGTTCGGTAGAAAGCCGCCAACGTATTCAAACCATGGCGGAAGATTTAAT
TCTTGAAACCGGTTTGCAACTGTTGCGAGAAGAATTAAATATATCGCAACAACAATTAGCTACGATTTTAGGTGTAACTC
AACCTGCAATTAATCAACTGGAACAGCGTGGCAATGAAATTAAGCTTGCAACCCTCAAACGTTACATCGAAGCAATGGGC
GGCAAATTACGCCTTAGTGTAGAAATGCCTGATGGACATCAGCGGGTTTTTCAAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References