Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3041798..3042492 Replicon chromosome
Accession NZ_CP064121
Organism Yersinia pestis strain M-1482

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag ISU58_RS13850 Protein ID WP_002214787.1
Coordinates 3042196..3042492 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag ISU58_RS13845 Protein ID WP_002209924.1
Coordinates 3041798..3042196 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU58_RS13810 3036988..3037353 + 366 WP_002209919.1 hypothetical protein -
ISU58_RS13815 3037366..3037602 + 237 WP_002214792.1 hypothetical protein -
ISU58_RS13820 3037608..3037940 + 333 WP_002214791.1 hypothetical protein -
ISU58_RS13825 3038122..3038322 + 201 WP_002209920.1 AlpA family transcriptional regulator -
ISU58_RS13830 3038336..3038488 - 153 WP_002209921.1 hypothetical protein -
ISU58_RS13835 3038481..3038807 - 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
ISU58_RS13840 3039107..3041398 + 2292 WP_002209923.1 toprim domain-containing protein -
ISU58_RS13845 3041798..3042196 - 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
ISU58_RS13850 3042196..3042492 - 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
ISU58_RS13855 3042656..3043018 - 363 WP_002209925.1 helix-turn-helix domain-containing protein -
ISU58_RS13860 3043081..3043341 - 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
ISU58_RS13865 3043939..3044124 + 186 WP_002209928.1 hypothetical protein -
ISU58_RS13870 3044206..3045420 - 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
ISU58_RS13880 3045853..3047370 - 1518 WP_002209930.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T180257 WP_002214787.1 NZ_CP064121:c3042492-3042196 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T180257 NZ_CP085094:1163098-1163397 [Aggregatibacter actinomycetemcomitans]
ATGATGATACAAATTAAGACGACTTTTCTTTTTGATGAATGGTTGAAGAAACTCAAAAACCTAAGAGCTAAAGCAAAAAT
CAACGCACGAATTAAACGGTTACAGTTTGGTAATTTCGGTGATTTAAAAAGCGTTAATGACGGCATATTTGAAATGCGGA
TTGATAAAGGTCAGGGGTATCGGGTTTATCTGAAAAATCAAAATGGCATACTTGTTATCCTGCTTTGTGGCGGAGACAAA
TCCACTCAAGAGAAAGATATCAAGAAAGCAAAACAACTTGCACAGGAAATGGGACTATGA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT180257 WP_002209924.1 NZ_CP064121:c3042196-3041798 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT180257 NZ_CP085094:1163394-1163690 [Aggregatibacter actinomycetemcomitans]
ATGAGTGAACAATTGAAAGATTTTGATCCTGCAGAATATTTATCTACCGAAGAAGATATTCGGCTTTATTTAAATGAAGT
GCTACAAGAAAATAATATTGAGCTTATTTTGTCTGCGTTAGGCGATATCGCACGAACCAGAAATATGAGCCAAATTGCCC
GCGAAACCGGTATGAGTAGAGAAGGGCTTTATAAAGCCCTGTCCGGTACGGGCAATCCTACCTTTGCCACCGTGATTAAA
GTCATGAAAGCCTTAAATTTACAACTCCAAGTGCAACCTTCCGGTTATGTTTCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References