Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 916095..916789 Replicon chromosome
Accession NZ_CP064120
Organism Yersinia pestis strain KM 567

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag ISU57_RS03805 Protein ID WP_002214787.1
Coordinates 916095..916391 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag ISU57_RS03810 Protein ID WP_002209924.1
Coordinates 916391..916789 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU57_RS03775 911217..912734 + 1518 WP_002209930.1 lysine--tRNA ligase -
ISU57_RS03785 913167..914381 + 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
ISU57_RS03790 914463..914648 - 186 WP_002209928.1 hypothetical protein -
ISU57_RS03795 915246..915506 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
ISU57_RS03800 915569..915931 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
ISU57_RS03805 916095..916391 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
ISU57_RS03810 916391..916789 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
ISU57_RS03815 917189..919480 - 2292 WP_002209923.1 toprim domain-containing protein -
ISU57_RS03820 919780..920106 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
ISU57_RS03825 920099..920251 + 153 WP_002209921.1 hypothetical protein -
ISU57_RS03830 920265..920465 - 201 WP_002209920.1 AlpA family transcriptional regulator -
ISU57_RS03835 920647..920979 - 333 WP_002214791.1 hypothetical protein -
ISU57_RS03840 920985..921221 - 237 WP_002214792.1 hypothetical protein -
ISU57_RS03845 921234..921599 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T180234 WP_002214787.1 NZ_CP064120:916095-916391 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T180234 NZ_CP085091:1505527-1505805 [Aggregatibacter actinomycetemcomitans]
ATGATTTTATCTTTCAAACATAAGGGACTTGAACAATTTTTTAAAACCGGTTCGACCGCAGGAATTCAAGCCAAACACGC
CAAGAAATTAAATCTGCAATTGGCCACATTAAATAATGCGGAAACGCCTCTTGCTATGAGTGTTCCCAGCTGGAATTTGC
ACAAACTTAAAGGTGATTTGCAAGAGCATTGGGCAGTTACCGTAAACGGAAATTGGCGCTTAACATTTAAATTTGAAAAT
GGTCATGCTGAAGTTGTTGATTATCAGGATTATCATTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT180234 WP_002209924.1 NZ_CP064120:916391-916789 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT180234 NZ_CP085091:1505821-1506093 [Aggregatibacter actinomycetemcomitans]
ATGCACAATCCTCCACACCCGGGAGAACTGTTAAAAGAATATATTGATGGCGTGAGTGTCACGAAGGTTGCCCAAAAATT
AGGTGTTTCGCGTGTTACGCTTTCCCGCATTCTTAATGGGAAAGCAAGTATAACGCCTGAAATGGCTGTGCGATTAAGCG
AATTATTGAATACCACAACACCGAAATTATGGCTGGGTATGCAAGCAGACTACGATTTATGGCAAATTGAACAACAACAC
GCCGTATTCAACATCCAACCATTATTTAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References