Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1465931..1466625 Replicon chromosome
Accession NZ_CP064119
Organism Yersinia pestis strain C-792

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag ISU56_RS06420 Protein ID WP_002214787.1
Coordinates 1466329..1466625 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag ISU56_RS06415 Protein ID WP_002209924.1
Coordinates 1465931..1466329 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU56_RS06380 1461121..1461486 + 366 WP_002209919.1 hypothetical protein -
ISU56_RS06385 1461499..1461735 + 237 WP_002214792.1 hypothetical protein -
ISU56_RS06390 1461741..1462073 + 333 WP_002214791.1 hypothetical protein -
ISU56_RS06395 1462255..1462455 + 201 WP_002209920.1 AlpA family transcriptional regulator -
ISU56_RS06400 1462469..1462621 - 153 WP_002209921.1 hypothetical protein -
ISU56_RS06405 1462614..1462940 - 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
ISU56_RS06410 1463240..1465531 + 2292 WP_002209923.1 toprim domain-containing protein -
ISU56_RS06415 1465931..1466329 - 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
ISU56_RS06420 1466329..1466625 - 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
ISU56_RS06425 1466789..1467151 - 363 WP_002209925.1 helix-turn-helix domain-containing protein -
ISU56_RS06430 1467214..1467474 - 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
ISU56_RS06435 1468072..1468257 + 186 WP_002209928.1 hypothetical protein -
ISU56_RS06440 1468451..1469234 - 784 Protein_1243 AAA family ATPase -
ISU56_RS06445 1469231..1470253 - 1023 WP_000255944.1 IS21-like element IS100 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T180221 WP_002214787.1 NZ_CP064119:c1466625-1466329 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T180221 NZ_CP085090:1135488-1135784 [Aggregatibacter actinomycetemcomitans]
ATGAGTGAACAATTGAAAGATTTTGATCCTGCAGAATATTTATCTACCGAAGAAGATATTCGGCTTTATTTAAATGAAGT
GCTACAAGAAAATAATATTGAGCTTATTTTGTCTGCGTTAGGCGATATCGCACGAACCAGAAATATGAGCCAAATTGCCC
GCGAAACCGGTATGAGTAGAGAAGGGCTTTATAAAGCCCTGTCCGGTACGGGCAATCCTACCTTTGCCACCGTGATTAAA
GTCATGAAAGCCTTAAATTTACAACTCCAAGTGCAACCTTCCGGTTATGTTTCTTAG

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT180221 WP_002209924.1 NZ_CP064119:c1466329-1465931 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT180221 NZ_CP085090:1135192-1135491 [Aggregatibacter actinomycetemcomitans]
ATGATGATACAAATTAAGACGACTTTTCTTTTTGATGAATGGTTGAAGAAACTCAAAAACCTAAGAGCTAAAGCAAAAAT
CAACGCACGAATTAAACGGTTACAGTTTGGTAATTTCGGTGATTTAAAAAGCGTTAATGACGGCATATTTGAAATGCGGA
TTGATAAAGGTCAGGGGTATCGGGTTTATCTGAAAAATCAAAATGGCATACTTGTTATCCTGCTTTGTGGCGGAGACAAA
TCCACTCAAGAGAAAGATATCAAGAAAGCAAAACAACTTGCACAGGAAATGGGACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References