Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3425764..3426458 Replicon chromosome
Accession NZ_CP064118
Organism Yersinia pestis strain C-783

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag ISU55_RS15630 Protein ID WP_002214787.1
Coordinates 3426162..3426458 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag ISU55_RS15625 Protein ID WP_002209924.1
Coordinates 3425764..3426162 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU55_RS15590 3420954..3421319 + 366 WP_002209919.1 hypothetical protein -
ISU55_RS15595 3421332..3421568 + 237 WP_002214792.1 hypothetical protein -
ISU55_RS15600 3421574..3421906 + 333 WP_002214791.1 hypothetical protein -
ISU55_RS15605 3422088..3422288 + 201 WP_002209920.1 AlpA family transcriptional regulator -
ISU55_RS15610 3422302..3422454 - 153 WP_002209921.1 hypothetical protein -
ISU55_RS15615 3422447..3422773 - 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
ISU55_RS15620 3423073..3425364 + 2292 WP_002209923.1 toprim domain-containing protein -
ISU55_RS15625 3425764..3426162 - 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
ISU55_RS15630 3426162..3426458 - 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
ISU55_RS15635 3426622..3426984 - 363 WP_002209925.1 helix-turn-helix domain-containing protein -
ISU55_RS15640 3427047..3427307 - 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
ISU55_RS15645 3427905..3428090 + 186 WP_002209928.1 hypothetical protein -
ISU55_RS15650 3428172..3429386 - 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
ISU55_RS15660 3429819..3431336 - 1518 WP_002209930.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T180218 WP_002214787.1 NZ_CP064118:c3426458-3426162 [Yersinia pestis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T180218 NZ_CP085089:1699443-1699697 [Aggregatibacter actinomycetemcomitans]
ATGATTTTAGCTTGGACGGAAACCGCCTGGGAAGATTATCTTTATTGGCAGCAAGTTGATAAAAAGACGTTGTTGCGCAT
TAATAAACTTATCCAAAATATTACCAGATCACCTTTCGAAGGCTTAGGCAATCCTGAACCTTTAAAACATCAGTTATCCG
GGTTTTGGTCTAGAAGAATAGATAAAGAGCATCGTCTTGTATACCAAGTATCGGATAGCCATTTAACGATTATTCAATGC
CGCTATCACTACTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT180218 WP_002209924.1 NZ_CP064118:c3426162-3425764 [Yersinia pestis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT180218 NZ_CP085089:1699195-1699446 [Aggregatibacter actinomycetemcomitans]
ATGAATGTAATAAGTTATTCTGCGTTTCGTGCAGAATTGGCAACCACACTTGATCAGGTGGTAGCAGATCATAGCCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTCGCAGCTTACGAAGAAACGGCTTATT
TATTACGCAGCCCCAAAAATAGAGAGCGTTTATTAGCCTCTATTGACCAGCTCAATTCAGGTAAAATCATCGAACGGGAA
CTCCAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References