Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 500113..500699 Replicon chromosome
Accession NZ_CP063992
Organism Klebsiella pneumoniae strain M164-1

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag HXS86_RS02630 Protein ID WP_002920800.1
Coordinates 500113..500481 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag HXS86_RS02635 Protein ID WP_004174006.1
Coordinates 500478..500699 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXS86_RS02610 (495616) 495616..496686 - 1071 WP_032433652.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
HXS86_RS02615 (496688) 496688..497533 - 846 WP_004145129.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
HXS86_RS02620 (497530) 497530..498417 - 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
HXS86_RS02625 (498524) 498524..499840 - 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
HXS86_RS02630 (500113) 500113..500481 - 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HXS86_RS02635 (500478) 500478..500699 - 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HXS86_RS02640 (500863) 500863..501576 - 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
HXS86_RS02645 (501578) 501578..502345 - 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
HXS86_RS02650 (502342) 502342..503619 - 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
HXS86_RS02655 (503616) 503616..504542 - 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 494879..503619 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T179919 WP_002920800.1 NZ_CP063992:c500481-500113 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T179919 NZ_CP084899:c1414805-1414611 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT179919 WP_004174006.1 NZ_CP063992:c500699-500478 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT179919 NZ_CP084899:1414434-1414612 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References