Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 473866..474512 Replicon chromosome
Accession NZ_CP063992
Organism Klebsiella pneumoniae strain M164-1

Toxin (Protein)


Gene name higB Uniprot ID A0A4S7KZ03
Locus tag HXS86_RS02520 Protein ID WP_032433636.1
Coordinates 474165..474512 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4S7L580
Locus tag HXS86_RS02515 Protein ID WP_019725405.1
Coordinates 473866..474165 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HXS86_RS02495 (470072) 470072..470830 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
HXS86_RS02500 (470880) 470880..471710 - 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
HXS86_RS02505 (471761) 471761..472090 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
HXS86_RS02510 (472295) 472295..473803 + 1509 WP_029602548.1 glycerol-3-phosphate dehydrogenase -
HXS86_RS02515 (473866) 473866..474165 - 300 WP_019725405.1 XRE family transcriptional regulator Antitoxin
HXS86_RS02520 (474165) 474165..474512 - 348 WP_032433636.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HXS86_RS02525 (474688) 474688..477135 - 2448 WP_032433638.1 glycogen phosphorylase -
HXS86_RS02530 (477153) 477153..478586 - 1434 WP_032433640.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13500.51 Da        Isoelectric Point: 6.2327

>T179918 WP_032433636.1 NZ_CP063992:c474512-474165 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGINEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T179918 NZ_CP084899:c1271086-1270979 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10775.53 Da        Isoelectric Point: 9.7681

>AT179918 WP_019725405.1 NZ_CP063992:c474165-473866 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKSYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT179918 NZ_CP084899:1271133-1271199 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S7KZ03

Antitoxin

Source ID Structure
AlphaFold DB A0A4S7L580

References