Detailed information of TA system TA179909

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4269273..4269531
• Replicon: chromosome
• Accession: NZ_CP063983
• Organism: Escherichia coli strain 25DN

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: IR210_RS20435
• Protein ID: WP_001181672.1
• Coordinates: 4269322..4269531 (+)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4269273..4269330 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IR210_RS20420	4265102..4266361	-	1260	WP_000494928.1	hypothetical protein	-
IR210_RS20425	4266490..4267983	-	1494	WP_001443162.1	sulfatase-like hydrolase/transferase	-
IR210_RS20430	4268003..4268764	-	762	WP_001274832.1	hypothetical protein	-
-	4269273..4269330	-	58	-	-	Antitoxin
IR210_RS20435	4269322..4269531	+	210	WP_001181672.1	type I toxin-antitoxin system Hok family toxin	Toxin
IR210_RS20440	4269636..4270766	-	1131	WP_001118465.1	molecular chaperone DnaJ	-
IR210_RS20445	4270855..4272771	-	1917	WP_000516135.1	molecular chaperone DnaK	-
IR210_RS20450	4273143..4273547	+	405	WP_000843687.1	DUF2541 family protein	-
IR210_RS20455	4273573..4274286	+	714	WP_001102391.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7757.25 Da
• Isoelectric Point: 9.3680

>T179909 WP_001181672.1 NZ_CP063983:4269322-4269531 [Escherichia coli]
MQNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T179909 NZ_CP084898:4458222-4458572 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT179909 NZ_CP063983:c4269330-4269273 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin