179880

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2741506..2741738 Replicon chromosome
Accession NZ_CP063980
Organism Enterococcus faecalis strain AR_0780

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag ISN59_RS12890 Protein ID WP_002355568.1
Coordinates 2741622..2741738 (-) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2741506..2741711 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISN59_RS12870 (2736994) 2736994..2738082 - 1089 WP_002355572.1 diacylglycerol kinase -
ISN59_RS12875 (2738101) 2738101..2739531 - 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
ISN59_RS12880 (2739521) 2739521..2740999 - 1479 WP_016622625.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
ISN59_RS12885 (2740999) 2740999..2741304 - 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
- (2741506) 2741506..2741711 + 206 NuclAT_2 - Antitoxin
ISN59_RS12890 (2741622) 2741622..2741738 - 117 WP_002355568.1 putative holin-like toxin Toxin
ISN59_RS12895 (2741886) 2741886..2743916 - 2031 WP_002364804.1 NAD-dependent DNA ligase LigA -
ISN59_RS12900 (2744042) 2744042..2746300 - 2259 WP_002363179.1 DNA helicase PcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T179880 WP_002355568.1 NZ_CP063980:c2741738-2741622 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

>T179880 NZ_CP063980:c2741738-2741622 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 206 bp

>AT179880 NZ_CP063980:2741506-2741711 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References