Detailed information of TA system TA179876

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 761184..761404
• Replicon: chromosome
• Accession: NZ_CP063980
• Organism: Enterococcus faecalis strain AR_0780

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: ISN59_RS03605
• Protein ID: WP_021164441.1
• Coordinates: 761184..761285 (+)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	761230..761404 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISN59_RS03590 (757621)	757621..758121	-	501	WP_010709949.1	cysteine hydrolase family protein	-
ISN59_RS03595 (758292)	758292..760562	+	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
ISN59_RS03600 (760750)	760750..760851	+	102	WP_075551663.1	putative holin-like toxin	-
- (760796)	760796..760975	-	180	NuclAT_5	-	-
- (760800)	760800..761009	-	210	NuclAT_4	-	-
ISN59_RS03605 (761184)	761184..761285	+	102	WP_021164441.1	putative holin-like toxin	Toxin
- (761230)	761230..761404	-	175	NuclAT_6	-	Antitoxin
- (761234)	761234..761441	-	208	NuclAT_3	-	-
ISN59_RS03610 (761467)	761467..761919	-	453	WP_002359057.1	YueI family protein	-
ISN59_RS03615 (762104)	762104..763051	+	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
ISN59_RS03620 (763048)	763048..764013	+	966	WP_016622541.1	iron chelate uptake ABC transporter family permease subunit	-
ISN59_RS03625 (764010)	764010..764765	+	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
ISN59_RS03630 (764804)	764804..765757	+	954	WP_010709946.1	siderophore ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3598.36 Da
• Isoelectric Point: 6.0656

>T179876 WP_021164441.1 NZ_CP063980:761184-761285 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

>T179876 NZ_CP084897:c3046898-3046491 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT179876 NZ_CP063980:c761404-761230 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAA
TCAGTAGTGCAACAA

Structures

Antitoxin