179866

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 586245..586581 Replicon chromosome
Accession NZ_CP063980
Organism Enterococcus faecalis strain AR_0780

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag ISN59_RS02815 Protein ID WP_002396786.1
Coordinates 586438..586581 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 586245..586294 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISN59_RS02810 (581552) 581552..586243 + 4692 WP_113843975.1 WxL domain-containing protein -
- (586245) 586245..586294 - 50 NuclAT_8 - Antitoxin
- (586244) 586244..586506 + 263 NuclAT_7 - -
ISN59_RS02815 (586438) 586438..586581 - 144 WP_002396786.1 putative holin-like toxin Toxin
ISN59_RS02820 (586851) 586851..588467 - 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -
ISN59_RS02825 (588929) 588929..590224 + 1296 WP_002410675.1 ATP-binding protein -
ISN59_RS02830 (590233) 590233..590865 + 633 WP_002358972.1 RloB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T179866 WP_002396786.1 NZ_CP063980:c586581-586438 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

>T179866 NZ_CP084897:1511610-1511786 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 50 bp

>AT179866 NZ_CP063980:c586294-586245 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References