Detailed information of TA system TA179865

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-RNAII/-
• Location: 586244..586581
• Replicon: chromosome
• Accession: NZ_CP063980
• Organism: Enterococcus faecalis strain AR_0780

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: ISN59_RS02815
• Protein ID: WP_002396786.1
• Coordinates: 586438..586581 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	586244..586506 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISN59_RS02810 (581552)	581552..586243	+	4692	WP_113843975.1	WxL domain-containing protein	-
- (586245)	586245..586294	-	50	NuclAT_8	-	-
- (586244)	586244..586506	+	263	NuclAT_7	-	Antitoxin
ISN59_RS02815 (586438)	586438..586581	-	144	WP_002396786.1	putative holin-like toxin	Toxin
ISN59_RS02820 (586851)	586851..588467	-	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
ISN59_RS02825 (588929)	588929..590224	+	1296	WP_002410675.1	ATP-binding protein	-
ISN59_RS02830 (590233)	590233..590865	+	633	WP_002358972.1	RloB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T179865 WP_002396786.1 NZ_CP063980:c586581-586438 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T179865 NZ_CP084897:c1414805-1414611 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Nucleotide

• Length: 263 bp

>AT179865 NZ_CP063980:586244-586506 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGACAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin