Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 5141276..5141922 Replicon chromosome
Accession NZ_CP063943
Organism Klebsiella pneumoniae strain BS329-2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ISA55_RS24830 Protein ID WP_194429468.1
Coordinates 5141276..5141623 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ISA55_RS24835 Protein ID WP_194429469.1
Coordinates 5141623..5141922 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA55_RS24820 5137202..5138635 + 1434 WP_002920564.1 glycogen synthase GlgA -
ISA55_RS24825 5138653..5141100 + 2448 WP_002920561.1 glycogen phosphorylase -
ISA55_RS24830 5141276..5141623 + 348 WP_194429468.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ISA55_RS24835 5141623..5141922 + 300 WP_194429469.1 helix-turn-helix transcriptional regulator Antitoxin
ISA55_RS24840 5141985..5143493 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
ISA55_RS24845 5143698..5144027 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
ISA55_RS24850 5144078..5144908 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
ISA55_RS24855 5144958..5145716 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(17-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13419.41 Da        Isoelectric Point: 6.2327

>T179784 WP_194429468.1 NZ_CP063943:5141276-5141623 [Klebsiella pneumoniae]
MWDVETTDTFDTGFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T179784 NZ_CP084894:c1414805-1414611 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10813.63 Da        Isoelectric Point: 10.6143

>AT179784 WP_194429469.1 NZ_CP063943:5141623-5141922 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAERRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNAPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT179784 NZ_CP084894:1414434-1414612 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References