Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1814611..1815208 Replicon chromosome
Accession NZ_CP063942
Organism Klebsiella quasipneumoniae strain BS418

Toxin (Protein)


Gene name higB Uniprot ID A0A3T0QUS6
Locus tag ISA61_RS08375 Protein ID WP_017899012.1
Coordinates 1814611..1814928 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ISA61_RS08380 Protein ID WP_106939351.1
Coordinates 1814921..1815208 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA61_RS08360 1810446..1811873 - 1428 WP_004202473.1 MFS transporter -
ISA61_RS08365 1811982..1812851 + 870 WP_017900842.1 helix-turn-helix transcriptional regulator -
ISA61_RS08370 1813384..1814427 + 1044 WP_194419260.1 DUF2157 domain-containing protein -
ISA61_RS08375 1814611..1814928 + 318 WP_017899012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ISA61_RS08380 1814921..1815208 + 288 WP_106939351.1 helix-turn-helix transcriptional regulator Antitoxin
ISA61_RS08385 1815466..1816119 - 654 WP_194419261.1 oxygen-insensitive NAD(P)H nitroreductase -
ISA61_RS08390 1816239..1816607 - 369 WP_004202487.1 MmcQ/YjbR family DNA-binding protein -
ISA61_RS08395 1816607..1817188 - 582 WP_017899014.1 TetR/AcrR family transcriptional regulator -
ISA61_RS08400 1817368..1818483 + 1116 WP_025999133.1 MBL fold metallo-hydrolase -
ISA61_RS08405 1818514..1818855 + 342 WP_004202492.1 RamA family antibiotic efflux transcriptional regulator -
ISA61_RS08410 1818873..1819121 - 249 WP_002893037.1 DUF1158 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12185.52 Da        Isoelectric Point: 11.2767

>T179755 WP_017899012.1 NZ_CP063942:1814611-1814928 [Klebsiella quasipneumoniae]
MFRMVVHVDVKKELQALPAIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQNKTLFLLRVF
VKKTQKTPLSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T179755 NZ_CP084893:c1270551-1270444 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10868.57 Da        Isoelectric Point: 10.2213

>AT179755 WP_106939351.1 NZ_CP063942:1814921-1815208 [Klebsiella quasipneumoniae]
MSKKIIDWDTLKTELLSQPEVQVAFDAQERQHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRTSLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT179755 NZ_CP084893:1270598-1270664 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0QUS6

Antitoxin

Source ID Structure

References