Detailed information of TA system TA179558

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3764..4028
• Replicon: plasmid pBM338-1.1
• Accession: NZ_CP063923
• Organism: Klebsiella pneumoniae strain BM338-1

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: -
• Locus tag: ISA71_RS26135
• Protein ID: WP_024179505.1
• Coordinates: 3764..3916 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	3968..4028 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISA71_RS26115	1234..1884	+	651	WP_194429320.1	plasmid IncI1-type surface exclusion protein ExcA	-
ISA71_RS26120	1956..2165	-	210	WP_000062603.1	HEAT repeat domain-containing protein	-
ISA71_RS26125	2558..2734	+	177	WP_180335155.1	hypothetical protein	-
ISA71_RS26130	3441..3692	+	252	WP_001291962.1	hypothetical protein	-
ISA71_RS26135	3764..3916	-	153	WP_024179505.1	Hok/Gef family protein	Toxin
-	3968..4028	+	61	NuclAT_0	-	Antitoxin
-	3968..4028	+	61	NuclAT_0	-	Antitoxin
-	3968..4028	+	61	NuclAT_0	-	Antitoxin
-	3968..4028	+	61	NuclAT_0	-	Antitoxin
ISA71_RS26140	4208..5416	+	1209	WP_064148469.1	IncI1-type conjugal transfer protein TrbA	-
ISA71_RS26145	5435..6505	+	1071	WP_094308841.1	IncI1-type conjugal transfer protein TrbB	-
ISA71_RS26150	6498..8789	+	2292	WP_077265944.1	conjugal transfer protein TrbC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..82097	82097

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5743.07 Da
• Isoelectric Point: 8.7948

>T179558 WP_024179505.1 NZ_CP063923:c3916-3764 [Klebsiella pneumoniae]
MPQRTFLMMLIVVCVTILCFVWIVRDSLCGLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

>T179558 NZ_CP084829:c4789833-4788916 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGACAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGTCTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT179558 NZ_CP063923:3968-4028 [Klebsiella pneumoniae]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Antitoxin