Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 699255..699901 Replicon chromosome
Accession NZ_CP063917
Organism Klebsiella variicola strain BM374-1

Toxin (Protein)


Gene name higB Uniprot ID A0A231WWF9
Locus tag ISA75_RS03585 Protein ID WP_004174016.1
Coordinates 699554..699901 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1F2LZT5
Locus tag ISA75_RS03580 Protein ID WP_008806992.1
Coordinates 699255..699554 (-) Length 100 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA75_RS03560 695462..696220 - 759 WP_008806995.1 DeoR/GlpR family transcriptional regulator -
ISA75_RS03565 696270..697100 - 831 WP_008806994.1 rhomboid family intramembrane serine protease GlpG -
ISA75_RS03570 697151..697480 - 330 WP_032733885.1 thiosulfate sulfurtransferase GlpE -
ISA75_RS03575 697684..699192 + 1509 WP_194400707.1 glycerol-3-phosphate dehydrogenase -
ISA75_RS03580 699255..699554 - 300 WP_008806992.1 helix-turn-helix transcriptional regulator Antitoxin
ISA75_RS03585 699554..699901 - 348 WP_004174016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ISA75_RS03590 700116..702563 - 2448 WP_008806990.1 glycogen phosphorylase -
ISA75_RS03595 702581..704014 - 1434 WP_194400709.1 glycogen synthase GlgA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-107)

Antitoxin

(31-84)


Sequences


Toxin        


Download         Length: 116 a.a.        Molecular weight: 13518.55 Da        Isoelectric Point: 6.2327

>T179485 WP_004174016.1 NZ_CP063917:c699901-699554 [Klebsiella variicola]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T179485 NZ_CP084779:c4481452-4481111 [Klebsiella quasipneumoniae subsp. similipneumoniae]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGACGCTATGTCTGTCGCCCGTAGCAGTGTGGCAAATGCTGCTTGC
ATGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATAACTTTGGCCGATGCCGTTAACTTTTTGGTAGAAAAGTACGAACTGGTTCGTATCGATCGCAGGGGATTC
AACTGGCAGGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCGCGGCAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10814.61 Da        Isoelectric Point: 10.1464

>AT179485 WP_008806992.1 NZ_CP063917:c699554-699255 [Klebsiella variicola]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT179485 NZ_CP084779:c4481814-4481473 [Klebsiella quasipneumoniae subsp. similipneumoniae]
ATGAAATATACTGACTCAGAGAACGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGTCGCTCG
TCTGGTACAGGAGGGAAACCGGCTGCACTATCTGGCTGACCGGGCCAGTATTACCGGTAAGTTCAGCGAAGCAGAATGTC
TTAAGCTGGATGTGGCATTCCCGCATTTTATCAGCCAGATGGAATCGATGCTGACTACTGGTGAAATGAATCCTTGCCAT
GCCCACTGTGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGC
CGTTTACCCCACTCATCGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A231WWF9


Antitoxin

Source ID Structure
AlphaFold DB A0A1F2LZT5

References