Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2411137..2411783 Replicon chromosome
Accession NZ_CP063906
Organism Klebsiella pneumoniae strain BM327-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ISA83_RS11925 Protein ID WP_194429468.1
Coordinates 2411436..2411783 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ISA83_RS11920 Protein ID WP_194429469.1
Coordinates 2411137..2411436 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA83_RS11900 2407343..2408101 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
ISA83_RS11905 2408151..2408981 - 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
ISA83_RS11910 2409032..2409361 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
ISA83_RS11915 2409566..2411074 + 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
ISA83_RS11920 2411137..2411436 - 300 WP_194429469.1 helix-turn-helix transcriptional regulator Antitoxin
ISA83_RS11925 2411436..2411783 - 348 WP_194429468.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ISA83_RS11930 2411959..2414406 - 2448 WP_002920561.1 glycogen phosphorylase -
ISA83_RS11935 2414424..2415857 - 1434 WP_002920564.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(17-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13419.41 Da        Isoelectric Point: 6.2327

>T179349 WP_194429468.1 NZ_CP063906:c2411783-2411436 [Klebsiella pneumoniae]
MWDVETTDTFDTGFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T179349 NZ_CP084705:1891547-1892032 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10813.63 Da        Isoelectric Point: 10.6143

>AT179349 WP_194429469.1 NZ_CP063906:c2411436-2411137 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAERRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNAPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT179349 NZ_CP084705:1891257-1891550 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References