Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4507636..4508233 Replicon chromosome
Accession NZ_CP063900
Organism Klebsiella quasipneumoniae strain BS324-2

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ISA86_RS21825 Protein ID WP_108450630.1
Coordinates 4507636..4507953 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ISA86_RS21830 Protein ID WP_108450629.1
Coordinates 4507946..4508233 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA86_RS21810 4503468..4504895 - 1428 WP_194417574.1 MFS transporter -
ISA86_RS21815 4505004..4505870 + 867 WP_158239951.1 helix-turn-helix transcriptional regulator -
ISA86_RS21820 4506408..4507451 + 1044 WP_060656299.1 hypothetical protein -
ISA86_RS21825 4507636..4507953 + 318 WP_108450630.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ISA86_RS21830 4507946..4508233 + 288 WP_108450629.1 helix-turn-helix transcriptional regulator Antitoxin
ISA86_RS21835 4508491..4509144 - 654 WP_108450628.1 oxygen-insensitive NAD(P)H nitroreductase -
ISA86_RS21840 4509264..4509632 - 369 WP_004202487.1 MmcQ/YjbR family DNA-binding protein -
ISA86_RS21845 4509632..4510213 - 582 WP_017899014.1 TetR/AcrR family transcriptional regulator -
ISA86_RS21850 4510393..4511508 + 1116 WP_072140403.1 MBL fold metallo-hydrolase -
ISA86_RS21855 4511539..4511880 + 342 WP_004202492.1 RamA family antibiotic efflux transcriptional regulator -
ISA86_RS21860 4511898..4512146 - 249 WP_002893037.1 DUF1158 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12197.57 Da        Isoelectric Point: 11.2767

>T179300 WP_108450630.1 NZ_CP063900:4507636-4507953 [Klebsiella quasipneumoniae]
MFRMVVHVDVKKELQALPAIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQNKTLFLLRVF
VKKTQKIPLSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T179300 NZ_CP084664:2129586-2129689 [Hafnia paralvei]
GCAAGGCAATCCAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCTGATAC
AGGAGTCGTATCAGGTCTTTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10840.56 Da        Isoelectric Point: 10.4518

>AT179300 WP_108450629.1 NZ_CP063900:4507946-4508233 [Klebsiella quasipneumoniae]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERKHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRTSLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT179300 NZ_CP084664:c2129691-2129548 [Hafnia paralvei]
ATAAAAAAAGACCTGATACGACTCCTGTATCAGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTTGGATTGCCTTGCTATTTAATAGTAGTCGACGATGCTTTTTTTTCCAGTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References