Detailed information of TA system TA179167

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2807928..2808604
• Replicon: chromosome
• Accession: NZ_CP063881
• Organism: Klebsiella pneumoniae strain S90-2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: W9BBY1
• Locus tag: IOD49_RS13565
• Protein ID: WP_016529833.1
• Coordinates: 2807928..2808275 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IOD49_RS13570
• Protein ID: WP_032413101.1
• Coordinates: 2808275..2808604 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IOD49_RS13555	2803854..2805287	+	1434	WP_002920564.1	glycogen synthase GlgA	-
IOD49_RS13560	2805305..2807752	+	2448	WP_102001163.1	glycogen phosphorylase	-
IOD49_RS13565	2807928..2808275	+	348	WP_016529833.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IOD49_RS13570	2808275..2808604	+	330	WP_032413101.1	helix-turn-helix transcriptional regulator	Antitoxin
IOD49_RS13575	2808637..2810145	-	1509	WP_002920554.1	glycerol-3-phosphate dehydrogenase	-
IOD49_RS13580	2810350..2810679	+	330	WP_002920552.1	thiosulfate sulfurtransferase GlpE	-
IOD49_RS13585	2810730..2811560	+	831	WP_004151408.1	rhomboid family intramembrane serine protease GlpG	-
IOD49_RS13590	2811610..2812368	+	759	WP_002920548.1	DeoR/GlpR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-107)

Antitoxin

• HigA2-like, helix-turn-helix domain (9-87)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13549.56 Da
• Isoelectric Point: 5.6749

>T179167 WP_016529833.1 NZ_CP063881:2807928-2808275 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Nucleotide

• Length: 348 bp

>T179167 NZ_CP084637:c3058160-3057738 [Yersinia ruckeri]
GTGGCCCAGTGGCGATGTGATCTGCGGGTTTCATGGCGCACCCAACTTTTCTCACTATTGGTACACGGTGTTCTGGTATT
ACTGACACTGGTGGTACCTTGGCCTGACGGATTTACTCCGCTATGGCTTATATTGCTGACGCTGGTGGTGTTTGAATGCA
TTCGCAGCCAGAAGAACATTACCTCTCGACAGGGAGAGATCCGGCTTAAAGCGGGAAATCTGTTGATTTGGAAGTGGCAA
GAGTGGACGTTGGTGCGGCCGCCGTGGATTACCCGCTACGGCGTATTATTATCGTTACAAGGCGCTGGCAGCCGCCGCCG
AAAACGTATTTGGCTAGCCTCCGACAGCATGTCGGAAGAAAAATGGCGCGAGTTGTGTCTGATATTACGACATACTTTTG
ATTCTGCGGCAGGCCGTGAGTAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11921.98 Da
• Isoelectric Point: 10.8046

>AT179167 WP_032413101.1 NZ_CP063881:2808275-2808604 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNLLTGIRAKRKP

Nucleotide

• Length: 330 bp

>AT179167 NZ_CP084637:c3058407-3058141 [Yersinia ruckeri]
ATGGAAATTGATAACAAAGCCCGAATCCATTGGGCATGCCGCCGGGGTATGCGTGAACTGGATATCTCCATAATGCCATT
TTTCGAACATGAATATGACACGCTAAACGATAATGATAAGCGCGTATTTATCCGCTTGCTGACGAGTGATGATCCTGATT
TATTCAATTGGTTGATGAACCACGGCGAGCCGCAGGATAGCGAACTGAAACGAATGGTTAAACTGATTCAGACACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTGA

Structures

Toxin

• AlphaFold DB: W9BBY1