Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2781740..2782326 Replicon chromosome
Accession NZ_CP063881
Organism Klebsiella pneumoniae strain S90-2

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag IOD49_RS13455 Protein ID WP_002920800.1
Coordinates 2781958..2782326 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag IOD49_RS13450 Protein ID WP_004174006.1
Coordinates 2781740..2781961 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD49_RS13430 2777897..2778823 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
IOD49_RS13435 2778820..2780097 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
IOD49_RS13440 2780094..2780861 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
IOD49_RS13445 2780863..2781576 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
IOD49_RS13450 2781740..2781961 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IOD49_RS13455 2781958..2782326 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
IOD49_RS13460 2782599..2783915 + 1317 WP_032435158.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
IOD49_RS13465 2784022..2784909 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
IOD49_RS13470 2784906..2785751 + 846 WP_004185988.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
IOD49_RS13475 2785753..2786823 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2778820..2787560 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T179166 WP_002920800.1 NZ_CP063881:2781958-2782326 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T179166 NZ_CP084637:c2098642-2098549 [Yersinia ruckeri]
TAAGCCTGCATGAAATGCCAACTTTTAGCGCACGGCTCTATCCCAAGAGCCATTTCCCTGGACCGAATATAGGATTCGTA
TTCGGTCTTTTTTT

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT179166 WP_004174006.1 NZ_CP063881:2781740-2781961 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT179166 NZ_CP084637:2098545-2098691 [Yersinia ruckeri]
AGTTAAAAAAAGACCGAATACGAATCCTATATTCGGTCCAGGGAAATGGCTCTTGGGATAGAGCCGTGCGCTAAAAGTTG
GCATTTCATGCAGGCTTATTAAGCCGTACCACTTAAGCGTAGTAGACGACCCACATTTTACCAATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References