Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1321909..1322506 Replicon chromosome
Accession NZ_CP063874
Organism Klebsiella quasipneumoniae strain S174-1

Toxin (Protein)


Gene name higB Uniprot ID A0A3T0QUS6
Locus tag IOD26_RS06620 Protein ID WP_017899012.1
Coordinates 1322189..1322506 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A3T0QUV3
Locus tag IOD26_RS06615 Protein ID WP_017899013.1
Coordinates 1321909..1322196 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD26_RS06585 1317996..1318244 + 249 WP_002893037.1 DUF1158 domain-containing protein -
IOD26_RS06590 1318262..1318603 - 342 WP_004202492.1 RamA family antibiotic efflux transcriptional regulator -
IOD26_RS06595 1318634..1319749 - 1116 WP_074440955.1 MBL fold metallo-hydrolase -
IOD26_RS06600 1319929..1320510 + 582 WP_200983273.1 TetR/AcrR family transcriptional regulator -
IOD26_RS06605 1320510..1320878 + 369 WP_004202487.1 MmcQ/YjbR family DNA-binding protein -
IOD26_RS06610 1320998..1321651 + 654 Protein_1301 oxygen-insensitive NAD(P)H nitroreductase -
IOD26_RS06615 1321909..1322196 - 288 WP_017899013.1 helix-turn-helix transcriptional regulator Antitoxin
IOD26_RS06620 1322189..1322506 - 318 WP_017899012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IOD26_RS06625 1322691..1323734 - 1044 WP_108450631.1 DUF2157 domain-containing protein -
IOD26_RS06630 1324267..1325136 - 870 WP_004202474.1 helix-turn-helix transcriptional regulator -
IOD26_RS06635 1325245..1326672 + 1428 WP_004202473.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12185.52 Da        Isoelectric Point: 11.2767

>T179119 WP_017899012.1 NZ_CP063874:c1322506-1322189 [Klebsiella quasipneumoniae]
MFRMVVHVDVKKELQALPAIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQNKTLFLLRVF
VKKTQKTPLSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T179119 NZ_CP084560:4455692-4455985 [Arthrobacter sp. FW306-2-2C-D06B]
GTGACCGGCCCAGAACCCACTGGCCCCGCAGCATGGAACGTCCAGGTCACCAGCCCGGCGCTGAGGGGCTTCAGGCGACT
GCCTGAGAAGGCCGCGGCAGCGATCGTCGAATTCGTCACGGGCGCACTCGCCGAGAACCCACACCGGCTGAGCAAGCCCC
TCACAAACGAACTGCTCGGACTCCGCACCGCCCGGCGCGGCGACTACAGGGTGCTGTTCACCCTGGACATCGAAGAGCAC
ACCCTGTACGTCCACCGCATCGAACACCGCTCCGACGTCTACAAACCGCGCTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10840.52 Da        Isoelectric Point: 10.2213

>AT179119 WP_017899013.1 NZ_CP063874:c1322196-1321909 [Klebsiella quasipneumoniae]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRTSLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT179119 NZ_CP084560:4455420-4455695 [Arthrobacter sp. FW306-2-2C-D06B]
ATGAGAACGGTACCGCTCAGCGAAGCCAAGGACAAGCTGTCCGCCCTCGTGGAGGAAGCAGACACGACCCACGAGATCAT
CCAAATCACCAGGCACGGGCACCCATCAGCCGTGCTGATGTCCGCCGATGACTTGGAATCCCTGCAGGAAACCATCCACT
GGCTGTCACAGCCGGGCATCCGCGAAGACCTGGACCAGGCCCGGCGCGACATCGCCGAGGGCAACACGACCAGCGGCGCA
GACCTCCGCCGTGAATTCGGGCTGCCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0QUS6

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0QUV3

References