Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
Location | 1321909..1322506 | Replicon | chromosome |
Accession | NZ_CP063874 | ||
Organism | Klebsiella quasipneumoniae strain S174-1 |
Toxin (Protein)
Gene name | higB | Uniprot ID | A0A3T0QUS6 |
Locus tag | IOD26_RS06620 | Protein ID | WP_017899012.1 |
Coordinates | 1322189..1322506 (-) | Length | 106 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | A0A3T0QUV3 |
Locus tag | IOD26_RS06615 | Protein ID | WP_017899013.1 |
Coordinates | 1321909..1322196 (-) | Length | 96 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IOD26_RS06585 | 1317996..1318244 | + | 249 | WP_002893037.1 | DUF1158 domain-containing protein | - |
IOD26_RS06590 | 1318262..1318603 | - | 342 | WP_004202492.1 | RamA family antibiotic efflux transcriptional regulator | - |
IOD26_RS06595 | 1318634..1319749 | - | 1116 | WP_074440955.1 | MBL fold metallo-hydrolase | - |
IOD26_RS06600 | 1319929..1320510 | + | 582 | WP_200983273.1 | TetR/AcrR family transcriptional regulator | - |
IOD26_RS06605 | 1320510..1320878 | + | 369 | WP_004202487.1 | MmcQ/YjbR family DNA-binding protein | - |
IOD26_RS06610 | 1320998..1321651 | + | 654 | Protein_1301 | oxygen-insensitive NAD(P)H nitroreductase | - |
IOD26_RS06615 | 1321909..1322196 | - | 288 | WP_017899013.1 | helix-turn-helix transcriptional regulator | Antitoxin |
IOD26_RS06620 | 1322189..1322506 | - | 318 | WP_017899012.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
IOD26_RS06625 | 1322691..1323734 | - | 1044 | WP_108450631.1 | DUF2157 domain-containing protein | - |
IOD26_RS06630 | 1324267..1325136 | - | 870 | WP_004202474.1 | helix-turn-helix transcriptional regulator | - |
IOD26_RS06635 | 1325245..1326672 | + | 1428 | WP_004202473.1 | MFS transporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12185.52 Da Isoelectric Point: 11.2767
>T179119 WP_017899012.1 NZ_CP063874:c1322506-1322189 [Klebsiella quasipneumoniae]
MFRMVVHVDVKKELQALPAIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQNKTLFLLRVF
VKKTQKTPLSEIRLALKRLEEMRNE
MFRMVVHVDVKKELQALPAIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQNKTLFLLRVF
VKKTQKTPLSEIRLALKRLEEMRNE
Download Length: 318 bp
>T179119 NZ_CP084560:4455692-4455985 [Arthrobacter sp. FW306-2-2C-D06B]
GTGACCGGCCCAGAACCCACTGGCCCCGCAGCATGGAACGTCCAGGTCACCAGCCCGGCGCTGAGGGGCTTCAGGCGACT
GCCTGAGAAGGCCGCGGCAGCGATCGTCGAATTCGTCACGGGCGCACTCGCCGAGAACCCACACCGGCTGAGCAAGCCCC
TCACAAACGAACTGCTCGGACTCCGCACCGCCCGGCGCGGCGACTACAGGGTGCTGTTCACCCTGGACATCGAAGAGCAC
ACCCTGTACGTCCACCGCATCGAACACCGCTCCGACGTCTACAAACCGCGCTAG
GTGACCGGCCCAGAACCCACTGGCCCCGCAGCATGGAACGTCCAGGTCACCAGCCCGGCGCTGAGGGGCTTCAGGCGACT
GCCTGAGAAGGCCGCGGCAGCGATCGTCGAATTCGTCACGGGCGCACTCGCCGAGAACCCACACCGGCTGAGCAAGCCCC
TCACAAACGAACTGCTCGGACTCCGCACCGCCCGGCGCGGCGACTACAGGGTGCTGTTCACCCTGGACATCGAAGAGCAC
ACCCTGTACGTCCACCGCATCGAACACCGCTCCGACGTCTACAAACCGCGCTAG
Antitoxin
Download Length: 96 a.a. Molecular weight: 10840.52 Da Isoelectric Point: 10.2213
>AT179119 WP_017899013.1 NZ_CP063874:c1322196-1321909 [Klebsiella quasipneumoniae]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRTSLDTLTR
YALACGIKHPQVLLY
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRTSLDTLTR
YALACGIKHPQVLLY
Download Length: 288 bp
>AT179119 NZ_CP084560:4455420-4455695 [Arthrobacter sp. FW306-2-2C-D06B]
ATGAGAACGGTACCGCTCAGCGAAGCCAAGGACAAGCTGTCCGCCCTCGTGGAGGAAGCAGACACGACCCACGAGATCAT
CCAAATCACCAGGCACGGGCACCCATCAGCCGTGCTGATGTCCGCCGATGACTTGGAATCCCTGCAGGAAACCATCCACT
GGCTGTCACAGCCGGGCATCCGCGAAGACCTGGACCAGGCCCGGCGCGACATCGCCGAGGGCAACACGACCAGCGGCGCA
GACCTCCGCCGTGAATTCGGGCTGCCGCCGCGGTGA
ATGAGAACGGTACCGCTCAGCGAAGCCAAGGACAAGCTGTCCGCCCTCGTGGAGGAAGCAGACACGACCCACGAGATCAT
CCAAATCACCAGGCACGGGCACCCATCAGCCGTGCTGATGTCCGCCGATGACTTGGAATCCCTGCAGGAAACCATCCACT
GGCTGTCACAGCCGGGCATCCGCGAAGACCTGGACCAGGCCCGGCGCGACATCGCCGAGGGCAACACGACCAGCGGCGCA
GACCTCCGCCGTGAATTCGGGCTGCCGCCGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3T0QUS6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3T0QUV3 |