Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 4749562..4750251 Replicon chromosome
Accession NZ_CP063871
Organism Klebsiella pneumoniae strain S141

Toxin (Protein)


Gene name higB Uniprot ID A0A331C6E2
Locus tag IRJ19_RS23105 Protein ID WP_021469727.1
Coordinates 4749562..4749879 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IRJ19_RS23110 Protein ID WP_040147778.1
Coordinates 4749955..4750251 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRJ19_RS23075 4745264..4745773 + 510 WP_002906702.1 GNAT family N-acetyltransferase -
IRJ19_RS23080 4745783..4746709 + 927 WP_032416224.1 amino acid ABC transporter permease -
IRJ19_RS23085 4746693..4747472 + 780 WP_002906697.1 amino acid ABC transporter ATP-binding protein -
IRJ19_RS23090 4747511..4748362 + 852 WP_014343117.1 transporter substrate-binding domain-containing protein -
IRJ19_RS23095 4748440..4749057 + 618 WP_040147782.1 glutathione S-transferase family protein -
IRJ19_RS23100 4749128..4749355 + 228 WP_002906690.1 tautomerase PptA -
IRJ19_RS23105 4749562..4749879 + 318 WP_021469727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IRJ19_RS23110 4749955..4750251 + 297 WP_040147778.1 helix-turn-helix domain-containing protein Antitoxin
IRJ19_RS23115 4750330..4750776 + 447 WP_004175959.1 hypothetical protein -
IRJ19_RS23120 4750817..4752433 - 1617 WP_040147777.1 carbohydrate porin -
IRJ19_RS23125 4752477..4753859 - 1383 WP_135620670.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-76)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12221.10 Da        Isoelectric Point: 10.2217

>T179111 WP_021469727.1 NZ_CP063871:4749562-4749879 [Klebsiella pneumoniae]
MLTFIELQGFSKRRQVLLQDDEFRAFQEILINDPEAGDTISGTGGFRKIRWSRPGMGKRGGVRVIYYNVTKKGRIYLALI
YPKNEQDELNQEQKKMLRQVADLIN

Download         Length: 318 bp

>T179111 NZ_CP084542:2184261-2184364 [Klebsiella michiganensis]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11032.88 Da        Isoelectric Point: 6.4721

>AT179111 WP_040147778.1 NZ_CP063871:4749955-4750251 [Klebsiella pneumoniae]
MKDELFADLLASAEEMVRIEKGEQMPMEQHVHTFSEIDVKAIREATGLKQQDFAAAVGVSYELVKSWETKRRQPTGAARK
LLLLLQGNPLIINLLKVV

Download         Length: 297 bp

>AT179111 NZ_CP084542:c2184371-2184203 [Klebsiella michiganensis]
AACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGTGTCAGGTTTTCCAGTCCGCGACAAAAGTG
GACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331C6E2

Antitoxin

Source ID Structure

References