Detailed information of TA system TA178946

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3040339..3041015
• Replicon: chromosome
• Accession: NZ_CP063844
• Organism: Streptomyces sp. A10(2020)

Toxin (Protein)

• Gene name: HigB2
• Uniprot ID: -
• Locus tag: IPZ55_RS13110
• Protein ID: WP_018471256.1
• Coordinates: 3040653..3041015 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IPZ55_RS13105
• Protein ID: WP_018471255.1
• Coordinates: 3040339..3040656 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IPZ55_RS13080 (IPZ55_12995)	3035635..3036696	+	1062	WP_030770447.1	hypothetical protein	-
IPZ55_RS13085 (IPZ55_13000)	3036902..3037432	+	531	WP_003949893.1	toxin-antitoxin system HicB family antitoxin	-
IPZ55_RS13090 (IPZ55_13005)	3037534..3038403	+	870	WP_129805594.1	DUF4097 family beta strand repeat-containing protein	-
IPZ55_RS13095 (IPZ55_13010)	3038507..3039481	+	975	WP_242577224.1	ATP-binding cassette domain-containing protein	-
IPZ55_RS13100 (IPZ55_13015)	3039478..3040260	+	783	WP_003949890.1	ABC transporter permease	-
IPZ55_RS13105 (IPZ55_13020)	3040339..3040656	-	318	WP_018471255.1	helix-turn-helix transcriptional regulator	Antitoxin
IPZ55_RS13110 (IPZ55_13025)	3040653..3041015	-	363	WP_018471256.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IPZ55_RS13115	3041014..3041907	+	894	WP_242576326.1	hypothetical protein	-
IPZ55_RS13120	3041826..3042710	+	885	WP_234364568.1	LPXTG cell wall anchor domain-containing protein	-
IPZ55_RS13125 (IPZ55_13035)	3042801..3043043	-	243	WP_008404832.1	hypothetical protein	-
IPZ55_RS13130 (IPZ55_13040)	3043347..3044201	+	855	WP_018893839.1	STAS domain-containing protein	-
IPZ55_RS13135 (IPZ55_13045)	3044198..3044578	+	381	WP_003949885.1	STAS domain-containing protein	-
IPZ55_RS13140 (IPZ55_13050)	3044578..3044994	+	417	WP_003949884.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-87)

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13502.36 Da
• Isoelectric Point: 4.6168

>T178946 WP_018471256.1 NZ_CP063844:c3041015-3040653 [Streptomyces sp. A10(2020)]
MDGEWQIFLVDEVRVWLASLDGAAHARVVQALDVLAEEGPALGRPLVDTLRGSAVANLKELRPGTVRILFAFDPWRSSIL
LVAGDKSGQWTEWYQEAIPLAEQRYALYLKEREREEGGRP

Nucleotide

• Length: 363 bp

>T178946 NZ_CP084432:2571966-2572169 [Edwardsiella tarda]
ATGACCAAAATAGACTATCTGATGAAGTTGCGTAAGTGCACGTCGCTGGAGACGCTAGAACGCGTGATCGAAAAGAATAA
ATATGAGCTTTCCAATGATGAGCTGGAAGTTTTTTATTCCGCAGCCGATCATCGCTTAGCCGAATTAACTATGAATAAGC
TATACGATAAAATTCCAGCCGAAGTCTGGCAGTACGTACGCTAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11558.05 Da
• Isoelectric Point: 9.8236

>AT178946 WP_018471255.1 NZ_CP063844:c3040656-3040339 [Streptomyces sp. A10(2020)]
MTSYTRWQDIRPEHVARAGGEEAVRAGKEELLAQVTGRKLAELRRARGLTQQEVADRMGVSKGRVSQIERGHLSGQEVLA
RFATALGGRLHQAIYFDDGDIATIA

Nucleotide

• Length: 318 bp

>AT178946 NZ_CP084432:2571577-2571945 [Edwardsiella tarda]
ATGGATGAGTACACATCTTATCGACATGACATCGCAGAGTTAAAATATCTGTGTGATTCCCTGTATCGTCAGGGAATGGA
TGTCCTGGAAGAGAGTCATCATGGCTGGGTCAGCGATCCGACGGCAATGGTTAATCTTCAGCTTAATGAGCTGATTGAGC
ATATTGCCAACGTGGCCTTGTCATTTAAGATCAAATATCCACAGCATTCGTCTCTTTGCGAAATAGTGGATGATTATCTG
GATGAAACCTATGCCTTGTTCAGCGCCTATAGCGTGAGTGAACAGGCACTCAGGCACTGGTTACGAAGCAAGCGCAGAGT
TGCGTACTCGCTCGCACATGAGAAACGTAACGCCGCCTTGCATGTTTAA