Detailed information of TA system TA178943

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1537967..1538625
• Replicon: chromosome
• Accession: NZ_CP063843
• Organism: Morganella morganii strain SMM01

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: IR188_RS07060
• Protein ID: WP_101924014.1
• Coordinates: 1537967..1538320 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: J7TDD0
• Locus tag: IR188_RS07065
• Protein ID: WP_004236876.1
• Coordinates: 1538323..1538625 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IR188_RS07050	1536147..1536404	-	258	WP_046024296.1	biofilm formation regulator BssS	-
IR188_RS07055	1536638..1537690	-	1053	WP_101924013.1	dihydroorotase	-
IR188_RS07060	1537967..1538320	+	354	WP_101924014.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IR188_RS07065	1538323..1538625	+	303	WP_004236876.1	XRE family transcriptional regulator	Antitoxin
IR188_RS07090	1539726..1540235	-	510	WP_004240013.1	YlaC family protein	-
IR188_RS07095	1540696..1540908	+	213	WP_004240014.1	transcription antiterminator/RNA stability regulator CspE	-
IR188_RS07100	1541012..1541206	+	195	WP_015422621.1	protein DsrB	-
IR188_RS07105	1541556..1542251	+	696	WP_004240015.1	MgtC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-81)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13548.55 Da
• Isoelectric Point: 10.1262

>T178943 WP_101924014.1 NZ_CP063843:1537967-1538320 [Morganella morganii]
VWKIVTTDNFTAWFAEQDDGDRAAILAAMLVLEKRGPGLPKPYADTVKGSRYTNMKELRIQSRGQPIRAFFAFAPERRGV
LLCAGYKTGKEKRFYMQMIPQADREYTEWLNRPENRS

Nucleotide

• Length: 354 bp

>T178943 NZ_CP084432:c1655621-1655292 [Edwardsiella tarda]
ATGAACTACACTATTGAGTACTACAGCGAAGAGGTTCGGCTTGAGGTCGATCGGTTGCCAATGGGTATGCGGGTTCGATA
CCAGCATCTCGTTGAACGCATGGAAATCTACGGTAGTAATCTCGGAGAACCACACACAAGCCCTTTTGGCGATGGGCTTT
TTGAGCTTCGAATCAAAGGCAGTGATGGCATCGCCCGCGTGTTTTACTGCACTCTTACCGGAAAACGTATCGTCATGCTG
CACAGCTTCATCAAGAAAACCCAGAAGACGCCAAGCGCTGAACGTAAGAAGGCTGAAACCAGAATGAAGGAGGTAAAACA
TGGCTGGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11108.00 Da
• Isoelectric Point: 9.5930

>AT178943 WP_004236876.1 NZ_CP063843:1538323-1538625 [Morganella morganii]
MGKSLRQLLAEEKPEVAAAARVQADEILLNIHLAELREKVKKTQVEMAQALGIKQPTVAGMEKPGRDVKLSTLRRYVDAI
GGKLNIDVELPDGTHYMFRV

Nucleotide

• Length: 303 bp

>AT178943 NZ_CP084432:c1655302-1654994 [Edwardsiella tarda]
ATGGCTGGTAAACGCACCCCCCCCACGATGACGCATGATGAAATGGCTGCAAAATGGATGGAAGACCCGGCATTTAAAGC
AGAATACGATGCCATCGAAGAGGAATACGCCCTACTCGATGAAATGCTCGCCGCCCGCAAAAACGCGGGGCTGACCCAGG
CGCAGGTCGCCGAACGTATGGGAACCAAGCCTACAGCGATCACTCGCATGGAAAGTAATTTAGCCTCCGGCCAAAGCGGG
CCATCATTCGCCACGCTGAAAAAATTTGCACACGCGACCGGCAAGAAACTGCAGATCCGGTTTGTCTGA

Structures

Antitoxin

• AlphaFold DB: J7TDD0