Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/VapI(antitoxin)
Location 3450115..3451562 Replicon chromosome
Accession NZ_CP063839
Organism Sphingopyxis granuli strain RW412

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ICN83_RS16050 Protein ID WP_212597500.1
Coordinates 3451227..3451562 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ICN83_RS16045 Protein ID WP_212597499.1
Coordinates 3450115..3451212 (-) Length 366 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICN83_RS16025 (ICN83_16045) 3445900..3446508 - 609 WP_212597495.1 hypothetical protein -
ICN83_RS16030 (ICN83_16050) 3446521..3447504 - 984 WP_212597496.1 hypothetical protein -
ICN83_RS16035 (ICN83_16055) 3448219..3449310 - 1092 WP_212597497.1 IS110 family transposase -
ICN83_RS16040 (ICN83_16060) 3449441..3450064 + 624 WP_212597498.1 S24 family peptidase -
ICN83_RS16045 (ICN83_16065) 3450115..3451212 - 1098 WP_212597499.1 HigA family addiction module antitoxin Antitoxin
ICN83_RS16050 (ICN83_16070) 3451227..3451562 - 336 WP_212597500.1 hypothetical protein Toxin
ICN83_RS21350 3451715..3453049 - 1335 WP_244857930.1 hypothetical protein -
ICN83_RS16060 (ICN83_16080) 3453267..3454316 + 1050 WP_212597501.1 hypothetical protein -
ICN83_RS16065 (ICN83_16085) 3454297..3454917 + 621 WP_212597502.1 thermonuclease family protein -
ICN83_RS16070 (ICN83_16090) 3454942..3455157 - 216 WP_126053373.1 AlpA family transcriptional regulator -
ICN83_RS16075 (ICN83_16095) 3455150..3455629 - 480 WP_244858169.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3436127..3465860 29733


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

IrrE N-terminal-like domain

(225-317)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12759.80 Da        Isoelectric Point: 7.4030

>T178939 WP_212597500.1 NZ_CP063839:c3451562-3451227 [Sphingopyxis granuli]
MDIDFRKRKLEKTFNAQAELLKAYGAPMAKAIMKRMTVLRAARDLSLVPVTPPERRHQLAEDRDEQFAVDLVHPKRLIFE
VNHDPIPRNEDGGIDLTKVTAITIIEVVDYH

Download         Length: 336 bp

>T178939 NZ_CP084430:1723115-1723216 [Edwardsiella piscicida]
GCAAGGCACTCAATGCCTGCATAATGCCAACTTTTAGCGCACGGCTCTCCAAAAGAGCCATTCCCCTAGACCTGACACAG
GAATCGTGTTAGGTCTTTTTTT

Antitoxin


Download         Length: 366 a.a.        Molecular weight: 40370.09 Da        Isoelectric Point: 7.2254

>AT178939 WP_212597499.1 NZ_CP063839:c3451212-3450115 [Sphingopyxis granuli]
MATAANQFRPDYAVPPGWILEERLEVHGMSQAEFARRCGRSAKLISEIIAGKAPLEPETAIQFEKVLGVDADLWLSIESG
YQLHRAREADAARAKDAIAWSKTFPINDLVKRRCFPKPVNPVDAVSKLLAFFGVGSLDAWNSQYGLAKVAYRHSPSFKSN
EVALATWLRLGELDAEQQECADYSETQFKLALKQIRALTREPVEQAIPLARALCNEAGVAVALVPPLAKTALSGAAWWIS
PRKPVIQLSARHKSDDHLWFSFFHEAAHILLHSKKSVFVDDKSRDGTDEEKEADAWACNTLVPTTAWRQFVATGPRSERA
VLDFADSQGIAPGIVVGMLQHSGILPWTHLNGLKIRLKWSTGAED

Download         Length: 1098 bp

>AT178939 NZ_CP084430:c1723218-1723108 [Edwardsiella piscicida]
ATAAAAAAAGACCTAACACGATTCCTGTGTCAGGTCTAGGGGAATGGCTCTTTTGGAGAGCCGTGCGCTAAAAGTTGGCA
TTATGCAGGCATTGAGTGCCTTGCTCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References