Detailed information of TA system TA178936

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 710923..711557
• Replicon: chromosome
• Accession: NZ_CP063839
• Organism: Sphingopyxis granuli strain RW412

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: ICN83_RS03340
• Protein ID: WP_244858052.1
• Coordinates: 711246..711557 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: ICN83_RS03335
• Protein ID: WP_212598193.1
• Coordinates: 710923..711243 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	710189..710554	365

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (1-91)

Antitoxin

• HigA2-like, helix-turn-helix domain (8-89)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11301.95 Da
• Isoelectric Point: 9.6550

>T178936 WP_244858052.1 NZ_CP063839:c711557-711246 [Sphingopyxis granuli]
MPDAVQDELLAATGLLELYGPRLGRPHADTLGGSRHANMRELRFNADGGVWRVAFAFDPERQAILLVAGDKAGVAQKRFY
KTLIGKADKRFDEHLAALAAKEK

Nucleotide

• Length: 312 bp

>T178936 NZ_CP084430:c1082896-1082693 [Edwardsiella piscicida]
ATGACCAAGATCGATTATCTGATGAAGCTGCGTAAATGCACGACGCTGGATACTCTAGAACGCGTGATCGAAAAGAATAA
ATACGAACTTTCAGATGATGAATTAGAAATTTTTTATTCTGCCGCAGATCATCGTCTGGCCGAATTAACTATGAATAAGC
TATACGACAAAATTCCAGCAGAAGTCTGGCAATACGTCCGCTAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11865.65 Da
• Isoelectric Point: 9.9148

>AT178936 WP_212598193.1 NZ_CP063839:c711243-710923 [Sphingopyxis granuli]
MGRSRSEIMATLPEDRRRRIEARAQELVAEVEGLKALRQLAERSQEQIAETLGVKQPSVHKIERQTDLYLSTLRRFVEAA
GGKLELRVELPGKGVLHLTGVGDLHA

Nucleotide

• Length: 321 bp

>AT178936 NZ_CP084430:c1083285-1082917 [Edwardsiella piscicida]
ATGGATGAGTACACTTCTTATCAGCATGACATCGCAGAGTTAAAATACCTGTGTGATTCTCTGTATCATCAGGGAATAGA
TGTCCTGGGAGAGAGCCATCACGGCTGGGTCAGCGACCCGACGGCAAAGGTAAATCTACAGCTTAATGAGTTGATTGAGC
ATATTGCCAGCGTCGCGCAATCATTTAAGATCAAATATCCGCATCATTCGGATTTAGCCGAAATATTGGATGATTATCTG
GATGAAACCTATGCCCTGTTTGGCGCCTATAGCGTCAGTGAAACGGCGCTCCGGCACTGGCTGCGCACCAAGCGGCGGGT
GGCATACTGCCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG