Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 710923..711557 Replicon chromosome
Accession NZ_CP063839
Organism Sphingopyxis granuli strain RW412

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ICN83_RS03340 Protein ID WP_244858052.1
Coordinates 711246..711557 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ICN83_RS03335 Protein ID WP_212598193.1
Coordinates 710923..711243 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICN83_RS03315 (ICN83_03320) 706166..706966 - 801 WP_212598190.1 inositol monophosphatase family protein -
ICN83_RS03320 (ICN83_03325) 707104..709110 + 2007 WP_212598191.1 phytase -
ICN83_RS03325 (ICN83_03330) 709664..710179 - 516 WP_212598192.1 hypothetical protein -
ICN83_RS03330 (ICN83_03335) 710219..710554 + 336 Protein_664 ATP-binding protein -
ICN83_RS03335 (ICN83_03340) 710923..711243 - 321 WP_212598193.1 XRE family transcriptional regulator Antitoxin
ICN83_RS03340 (ICN83_03345) 711246..711557 - 312 WP_244858052.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ICN83_RS03345 (ICN83_03350) 712138..712341 + 204 WP_067111562.1 AlpA family phage regulatory protein -
ICN83_RS03350 (ICN83_03355) 712354..713586 - 1233 Protein_668 tyrosine-type recombinase/integrase -
ICN83_RS03360 (ICN83_03365) 713916..715685 - 1770 WP_212598195.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 710189..710554 365


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(1-91)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-89)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11301.95 Da        Isoelectric Point: 9.6550

>T178936 WP_244858052.1 NZ_CP063839:c711557-711246 [Sphingopyxis granuli]
MPDAVQDELLAATGLLELYGPRLGRPHADTLGGSRHANMRELRFNADGGVWRVAFAFDPERQAILLVAGDKAGVAQKRFY
KTLIGKADKRFDEHLAALAAKEK

Download         Length: 312 bp

>T178936 NZ_CP084430:c1082896-1082693 [Edwardsiella piscicida]
ATGACCAAGATCGATTATCTGATGAAGCTGCGTAAATGCACGACGCTGGATACTCTAGAACGCGTGATCGAAAAGAATAA
ATACGAACTTTCAGATGATGAATTAGAAATTTTTTATTCTGCCGCAGATCATCGTCTGGCCGAATTAACTATGAATAAGC
TATACGACAAAATTCCAGCAGAAGTCTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11865.65 Da        Isoelectric Point: 9.9148

>AT178936 WP_212598193.1 NZ_CP063839:c711243-710923 [Sphingopyxis granuli]
MGRSRSEIMATLPEDRRRRIEARAQELVAEVEGLKALRQLAERSQEQIAETLGVKQPSVHKIERQTDLYLSTLRRFVEAA
GGKLELRVELPGKGVLHLTGVGDLHA

Download         Length: 321 bp

>AT178936 NZ_CP084430:c1083285-1082917 [Edwardsiella piscicida]
ATGGATGAGTACACTTCTTATCAGCATGACATCGCAGAGTTAAAATACCTGTGTGATTCTCTGTATCATCAGGGAATAGA
TGTCCTGGGAGAGAGCCATCACGGCTGGGTCAGCGACCCGACGGCAAAGGTAAATCTACAGCTTAATGAGTTGATTGAGC
ATATTGCCAGCGTCGCGCAATCATTTAAGATCAAATATCCGCATCATTCGGATTTAGCCGAAATATTGGATGATTATCTG
GATGAAACCTATGCCCTGTTTGGCGCCTATAGCGTCAGTGAAACGGCGCTCCGGCACTGGCTGCGCACCAAGCGGCGGGT
GGCATACTGCCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References