Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3840128..3840749 Replicon chromosome
Accession NZ_CP063785
Organism Tolypothrix sp. PCC 7712

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HGR01_RS15875 Protein ID WP_045872112.1
Coordinates 3840456..3840749 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HGR01_RS15870 Protein ID WP_045871837.1
Coordinates 3840128..3840442 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGR01_RS15860 (HGR01_15390) 3837348..3838652 + 1305 WP_194007890.1 HEAT repeat domain-containing protein -
HGR01_RS15865 (HGR01_15395) 3838778..3839530 - 753 WP_045871838.1 pentapeptide repeat-containing protein -
HGR01_RS15870 (HGR01_15400) 3840128..3840442 - 315 WP_045871837.1 HigA family addiction module antitoxin Antitoxin
HGR01_RS15875 (HGR01_15405) 3840456..3840749 - 294 WP_045872112.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HGR01_RS15880 (HGR01_15410) 3840875..3841822 + 948 WP_045871836.1 LysR family transcriptional regulator -
HGR01_RS15885 (HGR01_15415) 3841904..3842974 + 1071 WP_045871835.1 anthranilate phosphoribosyltransferase family protein -
HGR01_RS15890 (HGR01_15420) 3843112..3844014 - 903 WP_045871834.1 MBL fold metallo-hydrolase -
HGR01_RS15895 (HGR01_15425) 3844027..3844410 - 384 WP_045872111.1 aspartate 1-decarboxylase -
HGR01_RS15900 (HGR01_15430) 3844661..3845173 - 513 WP_045871833.1 inorganic diphosphatase -
HGR01_RS15905 (HGR01_15440) 3845544..3845729 - 186 WP_071989436.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-97)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-83)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11110.59 Da        Isoelectric Point: 6.4511

>T178835 WP_045872112.1 NZ_CP063785:c3840749-3840456 [Tolypothrix sp. PCC 7712]
MIVSFKNKATEDIFDGNDSKEARKQCPINCWGVAQRKLDQLNAAFSLDDMKVPPGNRLEALKGDRKGQHSIRINDQYRIC
FTWIPEGVSEVEIVDYH

Download         Length: 294 bp

>T178835 NZ_CP084336:c2325059-2324966 [Yersinia pestis]
TAAGCCTACATTAATACCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATCAGGAATCGTA
TTCGGTCTTTTTTT

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12030.75 Da        Isoelectric Point: 7.4026

>AT178835 WP_045871837.1 NZ_CP063785:c3840442-3840128 [Tolypothrix sp. PCC 7712]
MRVPKHRSPSHPGEILLKDFLEEMGISQRELADAIHVPYQRINEIVNQKRGITPSTALRLAKFFGNSSEFWLNLQQNWEL
YHVLLAEEAELKNIKQFKSSEATA

Download         Length: 315 bp

>AT178835 NZ_CP084336:2324965-2325059 [Yersinia pestis]
TAAAAAAAGACCGAATACGATTCCTGATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGT
ATTAATGTAGGCTTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References