Detailed information of TA system TA178809

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): pndA-rdlD/-
• Location: 3830435..3830699
• Replicon: chromosome
• Accession: NZ_CP063774
• Organism: Escherichia coli O25b:H4-ST131

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: U9Z417
• Locus tag: INT78_RS18220
• Protein ID: WP_001387489.1
• Coordinates: 3830547..3830699 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3830435..3830495 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INT78_RS18205	3826537..3827607	-	1071	WP_012783932.1	IncI1-type conjugal transfer protein TrbB	-
INT78_RS18210	3827626..3828834	-	1209	WP_001703845.1	IncI1-type conjugal transfer protein TrbA	-
-	3829014..3829071	-	58	NuclAT_13	-	-
-	3829014..3829071	-	58	NuclAT_13	-	-
-	3829014..3829071	-	58	NuclAT_13	-	-
-	3829014..3829071	-	58	NuclAT_13	-	-
INT78_RS18215	3829141..3830232	-	1092	WP_000426061.1	hypothetical protein	-
-	3830435..3830495	-	61	NuclAT_12	-	Antitoxin
-	3830435..3830495	-	61	NuclAT_12	-	Antitoxin
-	3830435..3830495	-	61	NuclAT_12	-	Antitoxin
-	3830435..3830495	-	61	NuclAT_12	-	Antitoxin
INT78_RS18220	3830547..3830699	+	153	WP_001387489.1	Hok/Gef family protein	Toxin
INT78_RS18225	3830771..3831022	-	252	WP_001291964.1	hypothetical protein	-
INT78_RS18230	3831322..3831618	+	297	WP_011264046.1	hypothetical protein	-
INT78_RS18235	3831683..3831859	-	177	WP_001054900.1	hypothetical protein	-
INT78_RS18240	3832251..3832460	+	210	WP_000062603.1	HEAT repeat domain-containing protein	-
INT78_RS18245	3832532..3833194	-	663	WP_012783935.1	plasmid IncI1-type surface exclusion protein ExcA	-
INT78_RS18250	3833265..3835433	-	2169	WP_015508354.1	DotA/TraY family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5761.10 Da
• Isoelectric Point: 8.7948

>T178809 WP_001387489.1 NZ_CP063774:3830547-3830699 [Escherichia coli O25b:H4-ST131]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

>T178809 NZ_CP084302:22529-22849 [Acinetobacter pseudolwoffii]
ATGTTATTTATTGAAACCAGCATCTTTACCAAGCAAATTAAAGACCTTGTATCTGATGAGGAATATCGTCAACTTCAGCA
AGATCTTTTGGTACAGCCTGATAGAGGTGACCTAATCAAGAATGGCGGTGGTATTCGCAAAGTACGTTGTGCTCAAGGTA
ACAAAGGGAAAAGTGGTGGGATACGGGTGATTTATTATTGGGTCACCGAGGATGATCAGATCTTTTTCTTAGTGGCTTAT
CCAAAATCAGTAAAAGATAATTTAACAGATAAGGAAACCGCCATTCTGCACCAACTCGTGAAGGAGCAATTTCATGGATA
A

Antitoxin

Nucleotide

• Length: 61 bp

>AT178809 NZ_CP063774:c3830495-3830435 [Escherichia coli O25b:H4-ST131]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Toxin

• AlphaFold DB: U9Z417

Antitoxin